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利什曼病住院犬的临床发现及死亡预后因素:一项回顾性研究

Clinical findings and prognostic factors for mortality in hospitalized dogs with leishmaniosis: aretrospective study.

作者信息

Molina Carlota Carvalho, Dias Maria Joana, Domingues Tiago Dias, Englar Ryane E, Leal Rodolfo Oliveira

机构信息

Hospital Escolar Veterinário, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.

Hospital Escolar Veterinário, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal; Centre for Interdisciplinary Research in Animal Health (CIISA) , Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal; Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), Lisbon, Portugal.

出版信息

Comp Immunol Microbiol Infect Dis. 2023 Oct;101:102041. doi: 10.1016/j.cimid.2023.102041. Epub 2023 Aug 23.

Abstract

This retrospective study evaluated factors responsible for mortality of dogs hospitalized for Canine Leishmaniosis. Medical records of 31 dogs with leishmaniosis from a Portuguese Veterinary Teaching Hospital were examined between August 2018 and January 2022. Females (n = 18) and pure breed dogs (n = 27) were overrepresented, with higher frequency of Labrador Retriever (n = 4). Median age was 7 years (interquartile range=7). Most had historical findings of lethargy (n = 26) and the commonest clinicopathological abnormality was hypoalbuminemia (n = 26). Eleven dogs were classified as LeishVet stage II, 10 stage III and 10 stage IV. Fourteen dogs (45.2%) died or were euthanized, with azotemia, leukocytosis, stage IV, absence of diagnosis before hospitalization and lack of leishmaniosis specific treatment during hospitalization contributing to mortality. Absence of hypoalbuminemia and stages II/III increased survival. Mean hospitalization length prior to discharge was 5.41days ( ± 1.84) and diarrhea prolonged hospital stay.

摘要

这项回顾性研究评估了因犬利什曼病住院的犬只死亡的相关因素。2018年8月至2022年1月期间,对葡萄牙一家兽医教学医院的31只患有利什曼病的犬只的病历进行了检查。雌性犬(n = 18)和纯种犬(n = 27)占比过高,其中拉布拉多寻回犬的出现频率更高(n = 4)。中位年龄为7岁(四分位间距 = 7)。大多数犬有嗜睡的既往史(n = 26),最常见的临床病理异常是低白蛋白血症(n = 26)。11只犬被分类为利什曼病兽医协会(LeishVet)II期,10只为III期,10只为IV期。14只犬(45.2%)死亡或被安乐死,氮质血症、白细胞增多、IV期、住院前未确诊以及住院期间缺乏利什曼病特异性治疗是导致死亡的原因。无低白蛋白血症以及II/III期可提高生存率。出院前的平均住院时长为5.41天(±1.84),腹泻会延长住院时间。

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