Université de Strasbourg, CNRS, Inserm, IGBMC UMR 7104- UMR-S 1258, F-67400 Illkirch, France.
Université de Strasbourg, CNRS, Inserm, IGBMC UMR 7104- UMR-S 1258, F-67400 Illkirch, France.
Steroids. 2023 Nov;199:109306. doi: 10.1016/j.steroids.2023.109306. Epub 2023 Aug 25.
Androgens are a class of steroid hormones primarily associated with male sexual development and physiology, but exert pleiotropic effects in either sex. They have a crucial role in various physiological processes, including the regulation of skeletal muscle and adipose tissue homeostasis. The effects of androgens are mainly mediated through the androgen receptor (AR), a ligand-activated nuclear receptor expressed in both tissues. In skeletal muscle, androgens via AR exert a multitude of effects, ranging from increased muscle mass and strength, to the regulation of muscle fiber type composition, contraction and metabolic functions. In adipose tissue, androgens influence several processes including proliferation, fat distribution, and metabolism but they display depot-specific and organism-specific effects which differ in certain context. This review further explores the potential mechanisms underlying androgen-AR signaling in skeletal muscle and adipose tissue. Understanding the roles of androgens and their receptor in skeletal muscle and adipose tissue is essential for elucidating their contributions to physiological processes, disease conditions, and potential therapeutic interventions.
雄激素是一类甾体激素，主要与男性的性发育和生理功能相关，但在两性中都发挥着多种效应。它们在各种生理过程中发挥着关键作用，包括骨骼肌肉和脂肪组织的稳态调节。雄激素的作用主要通过雄激素受体（AR）介导，AR 是一种配体激活的核受体，在这两种组织中均有表达。在骨骼肌肉中，雄激素通过 AR 发挥多种作用，从增加肌肉质量和力量，到调节肌肉纤维类型组成、收缩和代谢功能。在脂肪组织中，雄激素影响包括增殖、脂肪分布和代谢在内的多个过程，但它们具有组织特异性和机体特异性的效应，在某些情况下存在差异。本综述进一步探讨了雄激素-AR 信号在骨骼肌肉和脂肪组织中的潜在机制。了解雄激素及其受体在骨骼肌肉和脂肪组织中的作用对于阐明它们在生理过程、疾病状态和潜在治疗干预中的贡献至关重要。
