De Wolf-Peeters C, Stessens R, Desmet V, Tricot G, Verwilghen R L
Pathol Res Pract. 1986 Aug;181(4):402-7. doi: 10.1016/S0344-0338(86)80075-9.
Bone marrow biopsies of patients with a myelodysplastic syndrome (MDS) may, in the absence of an increased number of blasts in the bone marrow smears, contain small clusters of immature precursors. The presence of these cell nests, previously described as "abnormal localized immature precursors" or ALIP, bears a strong prognostic value predisposing patients to early death with an increased risk to develop myeloid leukaemia. In order to describe and delineate this histological characteristic more precisely, we compared bone biopsies of patients with MDS, used in these previous studies, with bone marrow biopsies performed for staging procedures in patients with Hodgkin's disease, non-Hodgkin's lymphoma and carcinoma. From this comparison we conclude that immature precursors are readily differentiated from proerythroblasts, myeloblasts and small-sized megakaryocytes, and that they most probably represent precursors of the myelo-monocytic-erythroid series. A clearcut increase in their number, mostly resulting in the formation of small clusters, is only found in biopsies from patients with MDS.
骨髓增生异常综合征（MDS）患者的骨髓活检，在骨髓涂片原始细胞数量未增加的情况下，可能含有小簇未成熟前体细胞。这些细胞巢的存在，以前被描述为“异常局限性未成熟前体细胞”或ALIP，具有很强的预后价值，使患者易早死，并增加发生髓系白血病的风险。为了更精确地描述和界定这一组织学特征，我们将先前这些研究中使用的MDS患者的骨活检与为霍奇金病、非霍奇金淋巴瘤和癌患者进行分期检查时所做的骨髓活检进行了比较。通过这一比较我们得出结论，未成熟前体细胞很容易与早幼红细胞、原始粒细胞和小型巨核细胞区分开来，并且它们很可能代表髓系-单核系-红系系列的前体细胞。仅在MDS患者的活检中发现其数量明显增加，大多形成小簇。
