Mangi M H, Salisbury J R, Mufti G J
Department of Haematological Medicine, King's College School of Medicine and Dentistry, Denmark Hill, London, U.K.
Leuk Res. 1991;15(7):627-39. doi: 10.1016/0145-2126(91)90032-o.
It has been suggested that the occurrence of abnormal localization of immature precursors (ALIP) in the bone marrow biopsy (BMB) may be of diagnostic and prognostic significance in myelodysplastic syndromes (MDS). The recognition of ALIP has been based exclusively on bone marrow histological appearances. During the last decade technical advances have led to the widespread use of various immunophenotypic markers for the diagnostic and prognostic purposes which has contributed enormously in understanding the development of haemopoietic cells and the cellular origin of various haematological malignancies. In addition proliferation antigens, growth factors, oncogenes, anti-oncogenes and other biological discoveries have opened new vistas to our knowledge of the normal and neoplastic growth processes. Despite this, the precise nature of ALIP and their significance in relation to the aetiopathogenesis and evolution of MDS remains unclear. Indeed the diagnostic value of ALIP in MDS is debatable. Furthermore, the precise cell lineages which comprise ALIP are not defined. The purpose of this review is to address these issues and to incorporate our new findings on the histological and immunophenotypic characterization of immature cell aggregates.
有人提出，骨髓活检（BMB）中未成熟前体细胞异常定位（ALIP）的出现可能在骨髓增生异常综合征（MDS）中具有诊断和预后意义。对ALIP的识别一直完全基于骨髓组织学表现。在过去十年中，技术进步导致各种免疫表型标志物被广泛用于诊断和预后目的，这在理解造血细胞的发育和各种血液系统恶性肿瘤的细胞起源方面做出了巨大贡献。此外，增殖抗原、生长因子、癌基因、抗癌基因和其他生物学发现为我们了解正常和肿瘤生长过程开辟了新的视野。尽管如此，ALIP的确切性质及其与MDS的病因发病机制和演变的关系仍不清楚。事实上，ALIP在MDS中的诊断价值存在争议。此外，构成ALIP的精确细胞谱系尚未明确。本综述的目的是解决这些问题，并纳入我们关于未成熟细胞聚集物的组织学和免疫表型特征的新发现。
