Tricot G, De Wolf-Peeters C, Vlietinck R, Verwilghen R L
Br J Haematol. 1984 Oct;58(2):217-25. doi: 10.1111/j.1365-2141.1984.tb06079.x.
A study has been performed of 40 bone marrow trephine biopsies from patients with myelodysplastic syndromes (MDS). Histology, more specifically the abnormal localization of immature precursors (ALIP), cytology and karyotype analysis were correlated with survival time and the prognostic value of these factors was determined. The presence or absence of ALIP proved to be highly significant in predicting the duration of survival (P = 0.007): the presence of ALIP predisposes patients to early death with high probability of developing acute myeloid leukaemia (AML), whereas the absence of ALIP carries a better prognosis with more long-term survivors and low probability of transformation to AML. The presence or absence of ALIP was not correlated with increased mortality from infection and/or bleeding. In contrast with ALIP, the main histological parameter, we were not able to obtain statistically significant prognostic information for cytology (FAB classification) or karyotype analysis (normal or abnormal chromosomes). We conclude that bone marrow biopsy provides useful information for the prognosis of MDS and that the presence of ALIP has greater predictive value than the more commonly used parameters deduced from cytology and karyotype.
对40例骨髓增生异常综合征（MDS）患者的骨髓环钻活检进行了一项研究。组织学，更具体地说是未成熟前体细胞异常定位（ALIP）、细胞学和核型分析与生存时间相关，并确定了这些因素的预后价值。结果表明，ALIP的存在与否在预测生存时间方面具有高度显著性（P = 0.007）：存在ALIP使患者易早死，发生急性髓系白血病（AML）的可能性高，而不存在ALIP则预后较好，长期存活者较多，转化为AML的可能性低。ALIP的存在与否与感染和/或出血导致的死亡率增加无关。与主要组织学参数ALIP不同，我们无法从细胞学（FAB分类）或核型分析（染色体正常或异常）中获得具有统计学意义的预后信息。我们得出结论，骨髓活检为MDS的预后提供了有用信息，并且ALIP的存在比从细胞学和核型中推导的更常用参数具有更大的预测价值。
