Gonzalez S, von Bassewitz D B, Grundmann E, Nakhosteen J A, Müller K M
Pathol Res Pract. 1986 Aug;181(4):408-17. doi: 10.1016/S0344-0338(86)80076-0.
170 consecutive biopsies from the bronchial tree were subjected to ultrastructural analysis. 62 were identified as preneoplastic lesions: of these, 7 as goblet cell hyperplasia, 20 as basal cell hyperplasia, 17 as combined goblet and basal cell hyperplasia, 10 as epidermoid metaplasia, and 8 as dysplasia. The ultrastructural features of these lesions are described. According to these results, preneoplastic lesions of the human bronchial mucosa are composed of heterogeneous populations that display mixed or combined morphologic features signaling abnormal differentiation patterns at this stage. The findings are tentatively correlated with bronchial carcinoma cell heterogeneity and histogenesis.
对取自支气管树的170份连续活检样本进行了超微结构分析。其中62份被鉴定为癌前病变：其中7份为杯状细胞增生，20份为基底细胞增生，17份为杯状细胞和基底细胞联合增生，10份为鳞状化生，8份为发育异常。描述了这些病变的超微结构特征。根据这些结果，人类支气管黏膜的癌前病变由异质性群体组成，这些群体呈现出混合或联合的形态学特征，表明该阶段存在异常分化模式。这些发现初步与支气管癌细胞的异质性和组织发生相关。
