Unidad de Gestión Clínica de Nefrología, Hospital Regional Universitario Carlos Haya, Instituto Biomédico de Investigación de Málaga (IBIMA), Universidad de Málaga, REDinREN, Málaga, Spain.
Sección de Inmunología, Hospital Regional Universitario Carlos Haya, Instituto Biomédico de Investigación de Málaga (IBIMA), Universidad de Málaga, REDinREN, Málaga, Spain.
Nefrologia (Engl Ed). 2023 May-Jun;43(3):281-292. doi: 10.1016/j.nefroe.2022.04.008. Epub 2023 Aug 25.
Although the results of kidney transplantation (KT) have improved substantially in recent years, a chronic and inexorable loss of grafts mainly due to the death of the patient and chronic dysfunction of the KT, continues to be observed. The objectives, thus, to optimize this situation in the next decade are fundamentally focused on minimizing the rate of kidney graft loss, improving patient survival, increasing the rate of organ procurement and its distribution, promoting research and training in health professionals and the development of scientific registries providing clinical and reliable information that allow us to optimize our clinical practice in the field of KT. With this perspective, this review will deep into: (1) strategies to avoid chronic dysfunction and graft loss in the medium and long term; (2) to prolong patient survival; (3) strategies to increase the donation, maintenance and allocation of organs; (4) promote clinical and basic research and training activity in KT; and (5) the analysis of the results in KT by optimizing and merging scientific registries.
尽管近年来肾移植（KT）的效果有了显著的提高，但仍观察到移植物的慢性和不可避免的损失，主要归因于患者的死亡和 KT 的慢性功能障碍。因此，在未来十年优化这一情况的目标主要集中在最大限度地降低肾移植失效率、提高患者生存率、提高器官采购及其分配率、促进卫生专业人员的研究和培训以及发展提供临床和可靠信息的科学登记册，以便我们能够优化 KT 领域的临床实践。有鉴于此，本次综述将深入探讨：（1）避免中、长期慢性功能障碍和移植物丢失的策略；（2）延长患者的生存时间；（3）增加器官捐赠、维护和分配的策略；（4）促进 KT 的临床和基础研究与培训活动；（5）通过优化和合并科学登记册分析 KT 的结果。
