Department of Pedodontics and Oral Dental Health, Al-Azhar University, Cairo, Egypt.
Department of Oral Biology, Al-Azhar University, Cairo, Egypt.
Niger J Clin Pract. 2023 Jul;26(7):856-862. doi: 10.4103/njcp.njcp_1731_21.
To histologically assess and compare formocresol (FC), platelet-rich fibrin (PRF), and hesperidin (HPN) as pulpotomy agents in dogs.
Pulpotomy was attempted from the buccal surface (class V) of 48 teeth in three mongrel dogs (Canis Lupus). Cavities were randomly allocated for three groups (n = 16) according to the pulpotomy agent used; (group I: FC (control), group II: PRF, and group III: HPN). All cavities were then sealed with zinc oxide eugenol followed by resin-modified glass ionomer restoration. Two months later, dogs were euthanized; the specimens were obtained and prepared for histological assessment followed by statistical analysis.
HPN specimens showed the best dentin bridge formation and the least inflammatory signs and pulp disorganization. Followed without statistically significant difference by PRF (P ≥ 0.05). Both of HPN and PRF, however, showed a significant difference statistically (P ≤ 0.05) to FC that showed no dentin bridging with more pronounced inflammation, necrosis, and pulp disorganization.
For pulpotomy, HPN and PRF seemed histologically to be good substitutes for FC in the dog model.
通过组织学评估比较甲醛甲酚（FC）、富血小板纤维蛋白（PRF）和橙皮苷（HPN）作为犬牙盖髓剂的效果。
从 3 只杂种犬（Canis Lupus）的颊面（V 类洞）进行了 48 颗牙的盖髓术。根据使用的盖髓剂将窝洞随机分配到 3 组（n = 16）；（I 组：FC（对照），II 组：PRF，III 组：HPN）。所有窝洞均用氧化锌丁香酚封闭，然后用树脂改良型玻璃离子水门汀修复。2 个月后，处死犬，获得标本，进行组织学评估，然后进行统计学分析。
HPN 标本显示出最佳的牙本质桥形成，炎症和牙髓组织紊乱最少。PRF 无显著差异（P≥0.05）。HPN 和 PRF 与 FC 相比均有统计学差异（P≤0.05），FC 无牙本质桥形成，炎症、坏死和牙髓组织紊乱更为明显。
在犬模型中，HPN 和 PRF 在组织学上似乎可以替代 FC 作为盖髓剂。
