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富血小板纤维蛋白与冻干血小板衍生制剂作为乳磨牙牙髓切断术药物的临床及影像学比较

A Clinical and Radiographic Comparison of Platelet-rich Fibrin and Lyophilized Platelet-derived Preparation as Pulpotomy Agent in Primary Molars.

作者信息

Devi Praja V, Muttath Anil L, Duraisamy Vinola, Selvarajan Nandhini B, Suresh Kumar V, Baby John John

机构信息

Department of Pediatric and Preventive Dentistry, Vinayaka Mission's Sankarachariyar Dental College, Vinayaka Missions Research Foundation-Deemed to be University, Salem, Tamil Nadu, India.

出版信息

J Pharm Bioallied Sci. 2020 Aug;12(Suppl 1):S155-S160. doi: 10.4103/jpbs.JPBS_48_20. Epub 2020 Aug 28.

DOI:10.4103/jpbs.JPBS_48_20
PMID:33149448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7595511/
Abstract

INTRODUCTION

Vital pulpotomy in primary molar teeth is aimed to retain the tooth in function until it is replaced by its successors.

AIM

The aim of this study was to evaluate and compare platelet-rich fibrin (PRF) and lyophilized platelet-derived preparation (LPDP) as a pulpotomy agent in primary molars.

MATERIALS AND METHODS

Forty primary molars from 20 healthy children aged 5-9 years requiring pulpotomy in the contralateral side of mandible were randomly selected. In both the groups, pulpotomy was carried out by removing coronal pulp and achieving hemostasis, the radicular part of pulp tissue was packed with PRF preparation in Group I and LPDP (Mothercell Research Centre, Trichy, Tamil Nadu, India) in Group II. The teeth were restored with zinc oxide eugenol and glass ionomer cement (GIC), followed by stainless steel crown in the same visit. Clinical and radiographic evaluation was undertaken at 1, 3, and 6 months interval.

RESULTS

The overall success rate was 90% in PRF group and 95% in LPDP group at the end of 6 months. The results were statistically nonsignificant between the groups ( > 0.05).

CONCLUSION

The overall outcome of the study suggests that PRF and LPDP are acceptable pulpotomy agents and are promising in the era of new vital pulp therapy procedure.

摘要

引言

乳牙活髓切断术旨在保留患牙行使功能，直至恒牙替换。

目的

本研究旨在评估和比较富血小板纤维蛋白（PRF）和冻干血小板衍生制剂（LPDP）作为乳牙活髓切断术药物的效果。

材料与方法

从20名5 - 9岁健康儿童中随机选取40颗需要在下颌对侧进行活髓切断术的乳牙。两组均通过去除冠髓并止血来实施活髓切断术，第一组用PRF制剂填充牙髓组织的根髓部分，第二组用LPDP（印度泰米尔纳德邦蒂鲁吉拉伯利的母细胞研究中心提供）填充。牙齿用氧化锌丁香酚和玻璃离子水门汀（GIC）修复，随后在同一次就诊时安装不锈钢冠。在术后1、3和6个月进行临床和影像学评估。

结果

6个月末，PRF组的总体成功率为90%，LPDP组为95%。两组结果在统计学上无显著差异（>0.05）。

结论

本研究的总体结果表明，PRF和LPDP都是可接受的活髓切断术药物，在新的牙髓保存治疗方法时代具有前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/5eb91ecad80c/JPBS-12-155-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/34c8dc4930f8/JPBS-12-155-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/e7d283ab133f/JPBS-12-155-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/5eb91ecad80c/JPBS-12-155-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/b2bdb7b1731c/JPBS-12-155-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/966d55b79f15/JPBS-12-155-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/161742ecacf4/JPBS-12-155-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/44918b3c7acf/JPBS-12-155-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/555b2e674b1d/JPBS-12-155-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/4b7d82bc28f1/JPBS-12-155-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/0913e48f4656/JPBS-12-155-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/34c8dc4930f8/JPBS-12-155-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/e7d283ab133f/JPBS-12-155-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4879/7595511/5eb91ecad80c/JPBS-12-155-g010.jpg

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