Ingerslev J, Mouritzen C, Stenbjerg S
Pharmatherapeutica. 1986;4(9):595-600.
A study was undertaken to investigate the possible interaction between pentoxifylline and coumarin. Ten patients on a previously stable anticoagulant treatment were investigated twice prior to, then 13 and 27 days after initiation of treatment with 1600 mg pentoxifylline daily. Coumarin therapy was continued in unaltered dosage. Parameters recorded were: bleeding time, platelet count, platelet adhesivity, spontaneous and collagen-induced platelet aggregation, activated partial thromboplastin time, prothrombin time, prothrombin-proconvertin activity, plasminogen activator and fibrin(ogen) degradation products. Platelet aggregation studies revealed a slightly higher sensitivity to collagen in 2 patients compared to pre-treatment values and in 1 patient the tendency to spontaneous aggregation was slightly increased after treatment. No other single test result changed significantly from premedication baseline values.
进行了一项研究以调查己酮可可碱与香豆素之间可能的相互作用。10名之前接受稳定抗凝治疗的患者在每日服用1600毫克己酮可可碱治疗前接受了两次检查，然后在治疗开始后的第13天和第27天又接受了检查。香豆素治疗剂量不变。记录的参数有：出血时间、血小板计数、血小板黏附性、自发和胶原诱导的血小板聚集、活化部分凝血活酶时间、凝血酶原时间、凝血酶原-前转变素活性、纤溶酶原激活剂以及纤维蛋白（原）降解产物。血小板聚集研究显示，与治疗前值相比，2名患者对胶原的敏感性略高，1名患者治疗后自发聚集的倾向略有增加。与用药前基线值相比，没有其他单项测试结果发生显著变化。
