体内血小板聚集抑制剂的研究。X. 与溶栓的关系。
Studies on platelet aggregation inhibitors in vivo. X. Relationship to thrombolysis.
作者信息
Ambrus J L, Ambrus C M, Sharma S D, Suh O W, Gastpar H
出版信息
J Med. 1982;13(5-6):365-71.
PMID:6221055
Abstract
Human labeled fibrin clots were inserted into femoral veins of stumptailed monkeys (Macaca arctoides). Thrombolysis was slightly increased by treatment with the platelet aggregation inhibitor pentoxifylline. This agent significantly potentiated the thrombolytic effect of urokinase activated human plasminogen. Pentoxifylline was also found to release plasminogen activator activity into the circulation.
摘要
将人体标记的纤维蛋白凝块植入短尾猴（熊猴）的股静脉。用血小板聚集抑制剂己酮可可碱治疗可使溶栓作用略有增强。该药物显著增强了尿激酶激活的人纤溶酶原的溶栓作用。还发现己酮可可碱可将纤溶酶原激活剂活性释放到循环中。
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