Silva Evânio Vilela, Silveira Heitor Albergoni, Moreira Thales Peres Candido, Augusto Jefferson, Silva Paula Verona Ragusa, Bufalino Andreia, León Jorge Esquiche
Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, (UNESP), Araraquara, Brazil.
Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Avenida do Caf?, S/N, 14040-904 Ribeirão Preto, SP Brazil.
Indian J Otolaryngol Head Neck Surg. 2023 Sep;75(3):2302-2305. doi: 10.1007/s12070-023-03609-4. Epub 2023 Feb 27.
Necrotizing sialometaplasia (NS) is a rare, self-limiting, necrotizing inflammatory lesion, often involving the minor salivary glands of the palate. NS occurs often in men (60%) older than 45 years. Commonly, it presents as an ulcerative lesion, measuring 1 to 3 cm in diameter, with an evolution time of a few weeks or days, simulating malignancy. However, in some instances, the mucosal surface is intact, thus emphasizing the importance of considering NS in the differential diagnosis of oral ulcerative and non-ulcerative lesions. To date, 12 cases of non-ulcerated NS in the palate have been reported. Here, we report a 50-year-old male patient who presented a non-ulcerated, asymptomatic, nodular swelling 3 months ago, located on the hard palate, clinically suggesting salivary gland tumor or lymphoproliferative disorder. After biopsy, a diagnosis of non-ulcerated NS was established. After 4 weeks, the lesion evolved with complete resolution. After literature review, notably, unlike ulcerated NS, the non-ulcerated NS affected patients a decade younger (33 years vs. 45 years), with marked female predilection (83% vs. 40%) and not uncommon bilateral presentation (33% vs. 10%). NS should be considered in the differential diagnosis of ulcerative and non-ulcerative lesions affecting the palate.
坏死性涎腺化生（NS）是一种罕见的、自限性的坏死性炎性病变，常累及腭部的小涎腺。NS常见于45岁以上的男性（60%）。通常表现为直径1至3厘米的溃疡性病变，病程为数周或数天，类似恶性肿瘤。然而，在某些情况下，黏膜表面完整，这凸显了在口腔溃疡性和非溃疡性病变鉴别诊断中考虑NS的重要性。迄今为止，已报道了12例腭部非溃疡性NS病例。在此，我们报告一名50岁男性患者，3个月前出现位于硬腭的非溃疡性、无症状结节性肿胀，临床提示涎腺肿瘤或淋巴增殖性疾病。活检后确诊为非溃疡性NS。4周后，病变完全消退。文献回顾显示，值得注意的是，与溃疡性NS不同，非溃疡性NS患者年龄小十岁（33岁对45岁），女性明显居多（83%对40%），双侧发病也不少见（33%对10%）。在腭部溃疡性和非溃疡性病变的鉴别诊断中应考虑NS。
