Fine A
Pharmacology. 1986;33(4):217-20. doi: 10.1159/000138219.
Acetazolamide was administered to normal dogs and its effects on total renal ammoniagenesis and glutamine extraction were studied. Urinary alkalinization resulted in diversion of urinary ammonia into the renal vein with no change in ammonia production or glutamine extraction. It is concluded that, contrary to reports about the rat, carbonic anhydrase inhibition has no effect on ammoniagenesis in vivo in the dog.
给正常犬施用乙酰唑胺，并研究其对肾脏总氨生成和谷氨酰胺摄取的影响。尿液碱化导致尿氨进入肾静脉，而氨生成或谷氨酰胺摄取无变化。得出的结论是，与关于大鼠的报道相反，碳酸酐酶抑制对犬体内的氨生成没有影响。
