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儿科头痛的诸多难题与误区中的回顾性观察研究:对诊断及干预效果的批判性分析

Retrospective Observational Study Amidst Myriad Conundrums and Myths of Pediatric Headaches: A Critique on Diagnostics and Effectiveness of Interventions.

作者信息

Khurana Priyal, Gupta Mayank, Gupta Nihit, Bansal Rajiv K, Jain Vivek

机构信息

Psychology, Christ University, Ghaziabad, IND.

Psychiatry and Behavioral Sciences, Southwood Psychiatric Hospital, Pittsburgh, USA.

出版信息

Cureus. 2023 Jul 25;15(7):e42424. doi: 10.7759/cureus.42424. eCollection 2023 Jul.

Abstract

Objective To study the etiological profile of pediatric headaches (PH) in a tertiary child neurology clinic and to determine the utility of diagnostics, interventions, and long-term prognosis. Methods Children (ages 4-15) observed over four years were recruited retrospectively. In primary headaches, the headache frequency and impact on quality of life (QOL) parameters at pre-treatment (T1) were compared post-treatment at follow-up (T2). Results Of the 311 eligible patients, 285 had primary headaches (Tension-Type Headache {TTH}: 156; Migraine: 129), and 26 had secondary headaches. The mean (±SD) onset age was 10 (±3) years with a male-to-female ratio of 2.3:1. Migraine was more common in children aged less than seven years (17/28) and TTH in older patients (146/283). The most common causes of secondary headache were intracranial hypertension (ICH) in 11/26 patients (four idiopathic intracranial hypertension (IIH), four following aseptic meningitis, three with cortical vein thrombosis), and ophthalmologic causes in 7/26 (of these five had convergence insufficiency). Hypertension was a rare cause of secondary headaches (2/26 patients). Neuroimaging was performed in 173/311 (56%), primarily for parental anxiety (160/173; 92%), and was abnormal in only four. At T2 (Median time to follow-up: 29 months; Interquartile range: 22-37 months), data were collected in 207/285 patients with primary headaches (TTH: 109; Migraine: 98). In both migraine and TTH groups, there were statistically significant reductions (p-value <0.0001) in headache frequency and QOL parameters. Conclusion In our study, TTH was the most common cause of PH. Neuroimaging was normal in most cases. Psychological interventions were effective but underutilized. The symptoms of primary headaches improved significantly over time, despite poor adherence to prophylactic medications.

摘要

目的 研究一家三级儿童神经科诊所中儿童头痛(PH)的病因谱,并确定诊断、干预措施及长期预后的效用。方法 回顾性招募观察四年的4至15岁儿童。在原发性头痛中,比较治疗前(T1)头痛频率及对生活质量(QOL)参数的影响与随访时治疗后的情况(T2)。结果 在311名符合条件的患者中,285例患有原发性头痛(紧张型头痛{TTH}:156例;偏头痛:129例),26例患有继发性头痛。平均(±标准差)发病年龄为10(±3)岁,男女比例为2.3:1。偏头痛在7岁以下儿童中更常见(17/28),而紧张型头痛在年龄较大患者中更常见(146/283)。继发性头痛最常见的原因是颅内高压(ICH),26例患者中有11例(4例特发性颅内高压{IIH},4例无菌性脑膜炎后,3例皮质静脉血栓形成),26例中有7例为眼科原因(其中5例有集合不足)。高血压是继发性头痛的罕见原因(2/26例患者)。311例中有173例(56%)进行了神经影像学检查,主要是因为家长焦虑(160/173;92%),仅4例异常。在T2(随访中位时间:29个月;四分位间距:22 - 37个月),收集了285例原发性头痛患者中207例的数据(紧张型头痛:109例;偏头痛:98例)。在偏头痛和紧张型头痛组中,头痛频率和生活质量参数均有统计学意义的降低(p值<0.0001)。结论 在我们的研究中,紧张型头痛是儿童头痛最常见的原因。大多数情况下神经影像学检查正常。心理干预有效但未得到充分利用。尽管预防性药物依从性差,但原发性头痛症状随时间显著改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c92/10448782/b0c12ea74cd7/cureus-0015-00000042424-i01.jpg

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