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Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes.色氨酸耗竭通过增加 AHR 表达和 GCN2/LAT1 介导的犬尿氨酸摄取来敏化 AHR 途径,并增强调节性 T 淋巴细胞的诱导。
J Immunother Cancer. 2023 Jun;11(6). doi: 10.1136/jitc-2023-006728.
2
The signaling function of IDO1 incites the malignant progression of mouse B16 melanoma.吲哚胺 2,3-双加氧酶 1(IDO1)的信号功能促使小鼠 B16 黑色素瘤的恶性进展。
Oncoimmunology. 2023 Jan 26;12(1):2170095. doi: 10.1080/2162402X.2023.2170095. eCollection 2023.
3
Heme Oxygenase-1: An Anti-Inflammatory Effector in Cardiovascular, Lung, and Related Metabolic Disorders.血红素加氧酶-1:心血管、肺部及相关代谢紊乱中的一种抗炎效应因子。
Antioxidants (Basel). 2022 Mar 15;11(3):555. doi: 10.3390/antiox11030555.
4
Editorial on Anticancer Antioxidants.关于抗癌抗氧化剂的社论
Antioxidants (Basel). 2021 Nov 8;10(11):1782. doi: 10.3390/antiox10111782.
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IDO Expression in Cancer: Different Compartment, Different Functionality?IDO 在癌症中的表达:不同部位,不同功能?
Front Immunol. 2020 Sep 24;11:531491. doi: 10.3389/fimmu.2020.531491. eCollection 2020.
6
TLR4 Signaling by Heme and the Role of Heme-Binding Blood Proteins.TLR4 信号转导与血红素结合血蛋白的作用。
Front Immunol. 2020 Aug 27;11:1964. doi: 10.3389/fimmu.2020.01964. eCollection 2020.
7
Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans.证据表明,犬尿氨酸途径的偏差会加重人类的动脉粥样硬化疾病。
J Intern Med. 2021 Jan;289(1):53-68. doi: 10.1111/joim.13142. Epub 2020 Aug 14.
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Tolerance to FVIII: Role of the Immune Metabolic Enzymes Indoleamine 2,3 Dyoxigenase-1 and Heme Oxygenase-1.对 FVIII 的耐受:免疫代谢酶吲哚胺 2,3 双加氧酶-1 和血红素加氧酶-1 的作用。
Front Immunol. 2020 Apr 15;11:620. doi: 10.3389/fimmu.2020.00620. eCollection 2020.
9
Heme Oxygenase Dependent Bilirubin Generation in Vascular Cells: A Role in Preventing Endothelial Dysfunction in Local Tissue Microenvironment?血管细胞中血红素加氧酶依赖性胆红素生成:在局部组织微环境中预防内皮功能障碍的作用?
Front Physiol. 2020 Jan 29;11:23. doi: 10.3389/fphys.2020.00023. eCollection 2020.
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Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation.吲哚胺 2,3-双加氧酶 1 的正变构调节抑制神经炎症。
Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3848-3857. doi: 10.1073/pnas.1918215117. Epub 2020 Feb 5.

Editorial: Heme proteins: key players in the regulation of immune responses.

作者信息

Volpi Claudia, Van den Eynde Benoît J, Orabona Ciriana

机构信息

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Ludwig Institute for Cancer Research, Brussels, Belgium.

出版信息

Front Immunol. 2023 Aug 9;14:1263384. doi: 10.3389/fimmu.2023.1263384. eCollection 2023.

DOI:10.3389/fimmu.2023.1263384
PMID:37638027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10450145/
Abstract
摘要