Mollahoseini Foomani Farzad, Sadeghian Mohammad Hadi, Bagheri Saeede, Badiee Zahra, Bazargani Reihane, Aryanpour Zahra, Hallajiayan Saeid, Shams Seyyede Fatemeh
Blood Transfusion Organization Research Center, Iranian blood transfusion organization, Mashhad, Iran.
Cancer Molecular Pathology Research Center. Mashhad University of Medical Sciences. Mashhad, Iran.
Int J Hematol Oncol Stem Cell Res. 2023 Jan 1;17(1):4-8. doi: 10.18502/ijhoscr.v17i1.11707.
Thalassemia is an inherited disease with anemia and hemolysis. Blood transfusion is a routine treatment for thalassemia patients; alloimmunization is one of the complications of blood transfusion, which is very serious for these patients, especially girls and young women. In this cross-sectional study, 446 thalassemia patients were examined. Demographic information of patients was extracted and recorded. The phenotype of ABO, Rh, and Kell antigens (tube method) with antisera from IMMUNDIANOSTICA Company (Germany) and the frequency of alloantibodies were determined. 55.8% of the studied individuals were male, and 44.2% were female. Mean age of the studied patients was 19.94±10.63. The alloantibodies were detected in 7.5% of cell-pack receivers. The most prevalent phenotype of the ABO system was the O blood group (37.4%), and the most abundant antigen of the Rh group was 'e', which was found in 99.8% of the studied population. The most common alloantibody detected was Anti K (38.2%); concerning kell phenotype, (Kk) and (Kk) were found in 99.3% and 0.7% of patients, respectively. The frequency of Anti-D, Anti-C, Anti-c, and Anti-E was 23.5%, 14.7%, 2.9%, and 14.7%, respectively. According to the results of this paper, finding the compatible packed cells in terms of Kell and Rh systems antigens in addition to the ABO blood group is recommended to decrease the rate of alloantibodies in thalassemia patients.
地中海贫血是一种伴有贫血和溶血的遗传性疾病。输血是地中海贫血患者的常规治疗方法；同种免疫是输血的并发症之一，对这些患者，尤其是女孩和年轻女性来说非常严重。在这项横断面研究中，对446例地中海贫血患者进行了检查。提取并记录了患者的人口统计学信息。使用德国IMMUNDIANOSTICA公司的抗血清，通过试管法测定ABO、Rh和Kell抗原的表型以及同种抗体的频率。研究对象中55.8%为男性，44.2%为女性。研究患者的平均年龄为19.94±10.63岁。在7.5%的红细胞输注接受者中检测到了同种抗体。ABO系统中最常见的表型是O血型（37.4%），Rh组中最常见的抗原是“e”，在99.8%的研究人群中发现。检测到的最常见同种抗体是抗K（38.2%）；关于Kell表型，（Kk）和（Kk）分别在99.3%和0.7%的患者中发现。抗-D、抗-C、抗-c和抗-E的频率分别为23.5%、14.7%、2.9%和14.7%。根据本文结果，建议除ABO血型外，在Kell和Rh系统抗原方面找到相容的红细胞，以降低地中海贫血患者同种抗体的发生率。
