Avagimyan Ashot, Fogacci Federica, Pogosova Nana, Kakrurskiy Lev, Kogan Eugenia, Urazova Olga, Kobalava Zhanna, Mikhaleva Liudmila, Vandysheva Rositsa, Zarina Gioeva, Trofimenko Artem, Navasardyan Grizelda, Mkrtchyan Lusine, Galli Mattia, Jndoyan Zinaida, Aznauryan Anait, Saahakyan Karmen, Agati Luciano, Shafie Davood, Cicero Arrigo, Salvo Giovanni Di, Sarrafzadegan Nizal
Anatomical Pathology and Clinical Morphology Department, Yerevan State Medical University, Yerevan, Armenia.
Atherosclerosis and Metabolic Disorders Unit, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Curr Probl Cardiol. 2024 Jan;49(1 Pt A):102052. doi: 10.1016/j.cpcardiol.2023.102052. Epub 2023 Aug 26.
Diabetes mellitus (DM) is considered by many the pandemic of the 21st century and is associated with multiple organ damages. Among these, cardiovascular complications are responsible for an incredible burden of mortality and morbidity in Western Countries. The study of the pathological mechanisms responsible for the cardiovascular complications in DM patients is key for the development of new therapeutic strategies. The metabolic disorders caused by hyperglycemia, insulin resistance, and dyslipidemia, results in a cascade of pathomorphological changes favoring the atherosclerotic process and leading to myocardial remodeling. Parallel to this, oxidative stress, calcium overload, mitochondrial dysfunction, activation of protein kinase C signaling pathways, myocardial lipomatosis, and low-grade inflammation of the myocardium - are the main pathways responsible for the diabetic cardiomyopathy development. This review aims to appraise and discuss the pathogenetic mechanisms behind the diabetic cardiomyopathy development.
糖尿病（DM）被许多人视为21世纪的大流行病，并且与多器官损害相关。其中，心血管并发症在西方国家造成了令人难以置信的死亡率和发病率负担。研究糖尿病患者心血管并发症的病理机制是开发新治疗策略的关键。高血糖、胰岛素抵抗和血脂异常引起的代谢紊乱，会导致一系列有利于动脉粥样硬化进程并导致心肌重塑的病理形态学变化。与此同时，氧化应激、钙超载、线粒体功能障碍、蛋白激酶C信号通路激活、心肌脂肪变性和心肌低度炎症——是导致糖尿病性心肌病发展的主要途径。本综述旨在评估和讨论糖尿病性心肌病发展背后的发病机制。
