Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Dentist, Faculty of Dentistry, Tehran Medical Sciences. Islamic Azad University, Tehran, Iran.
Photodiagnosis Photodyn Ther. 2023 Dec;44:103770. doi: 10.1016/j.pdpdt.2023.103770. Epub 2023 Aug 26.
The aim of this study was to evaluate the inactivation potency of riboflavin and curcumin plus blue diode laser against Streptococcus mutans with different power densities.
In this in vitro study, standard-strain S. mutans was exposed to curcumin and riboflavin plus blue diode laser with different power densities (0.4-1.0 W/cm) as well as chlorhexidine (CHX). The colony forming units (CFUs)/mL was calculated. Data were analyzed by one-way ANOVA.
Antibacterial analysis indicated that the blue diode laser irradiation with curcumin and riboflavin provided a satisfactory reduction of the S. mutans level. In addition, S. mutans was more affected by curcumin + blue diode laser when the power density was set to 1.0 W/cm (P < 0.0001). Meanwhile, bacterial suspensions treated with CHX showed maximum colony number reduction, compared with the control (P < 0.0001).
This study showed the blue diode laser along with curcumin had strong bactericidal effect on S. mutans, and this effect improved by increasing the power density.
本研究旨在评估核黄素和姜黄素联合蓝光二极管激光在不同功率密度下对变形链球菌的失活效力。
在这项体外研究中，标准株变形链球菌分别用不同功率密度（0.4-1.0 W/cm）的姜黄素和核黄素联合蓝光二极管激光以及洗必泰（CHX）进行处理。计算菌落形成单位（CFU/mL）。采用单因素方差分析进行数据分析。
抗菌分析表明，蓝光二极管激光联合姜黄素和核黄素照射能显著降低变形链球菌水平。此外，当功率密度设置为 1.0 W/cm 时，变形链球菌受姜黄素+蓝光二极管激光的影响更大（P<0.0001）。同时，与对照组相比，经 CHX 处理的细菌悬液显示出最大的菌落数减少（P<0.0001）。
本研究表明，蓝光二极管激光联合姜黄素对变形链球菌具有较强的杀菌作用，且通过增加功率密度可提高其杀菌效果。
