School of Social Work, University of Maryland Baltimore, Baltimore, Maryland, USA
School of Social Work, University of Maryland Baltimore, Baltimore, Maryland, USA.
BMJ Open. 2023 Aug 28;13(8):e073877. doi: 10.1136/bmjopen-2023-073877.
Transgender and gender non-binary (TNB) youth living in the USA report elevated levels of substance use compared with their cisgender counterparts, with previous literature pointing to minority stressors as some of the factors that could facilitate such elevated levels. Yet, substance use and misuse prevalence and associated modifiable factors among TNB youth are not fully known. The current paper details the protocol for a systematic review aimed at (1) identifying substance use and misuse prevalence among TNB youth (ages <25) and related demographic disparities (based on racial, ethnic and gender identity, and sexual orientation), (2) examining factors associated with substance use and misuse among TNB youth and (3) examining protective factors against substance use and misuse among TNB youth.
Systematic searches will be conducted across four databases: PubMed, LGBTQ+ Source, CINAHL and PsycInfo to identify quantitative, qualitative and mixed-methods peer-reviewed research publications. An exhaustive list of keywords and corresponding MeSH (Medical Subject Headings) terms representing the concepts of 'TNB' (the population of interest) and 'substance use and misuse' (outcome) will be employed. Identified records will be initially screened via a review of titles and abstracts. Full text of the remaining records will be reviewed corresponding to the inclusion and exclusion criteria. Extracted data will be synthesised in table and narrative format. A meta-analysis will be considered contingent on the existence of sufficient data. Methodological quality and risk of bias of studies will be assessed.
This review does not require approval from the Institutional Review Board as it involves no interactions with human subjects. We will disseminate our findings via peer-reviewed manuscripts and academic conference presentations.
CRD42023394985.
与顺性别同龄人相比，生活在美国的跨性别和性别非二元（TNB）青年报告的物质使用水平较高，先前的文献指出，少数群体压力是导致这种高水平的因素之一。然而，TNB 青年的物质使用和滥用的流行率以及相关的可改变因素尚不完全清楚。本论文详细介绍了一项系统评价的方案，旨在：（1）确定 TNB 青年（年龄<25 岁）的物质使用和滥用流行率以及相关的人口统计学差异（基于种族、族裔和性别认同以及性取向）；（2）检查与 TNB 青年物质使用和滥用相关的因素；（3）检查 TNB 青年预防物质使用和滥用的保护因素。
将在四个数据库中进行系统搜索：PubMed、LGBTQ+ Source、CINAHL 和 PsycInfo，以确定定量、定性和混合方法的同行评审研究出版物。将使用代表“TNB”（感兴趣的人群）和“物质使用和滥用”（结果）概念的关键词和相应的 MeSH（医学主题词）术语的详尽列表。将通过审查标题和摘要初步筛选已识别的记录。将根据纳入和排除标准审查其余记录的全文。提取的数据将以表格和叙述格式综合。将根据存在足够的数据考虑进行荟萃分析。将评估研究的方法学质量和偏倚风险。
本综述不需要机构审查委员会的批准，因为它不涉及与人类受试者的任何互动。我们将通过同行评议的手稿和学术会议报告来传播我们的发现。
PROSPERO 注册号：CRD42023394985。
