Wang Jiangen, Liu Juhong, Guo Zilong
Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Fuzhou Institute for Data Technology Co., Ltd., Fuzhou 350207, China.
Trends Plant Sci. 2024 Mar;29(3):290-302. doi: 10.1016/j.tplants.2023.07.005. Epub 2023 Aug 26.
Taking advantage of natural variation promotes our understanding of phenotypic diversity and trait evolution, ultimately accelerating plant breeding, in which the identification of causal variations is critical. To date, sequence variations in the coding region and transcription level polymorphisms caused by variations in the promoter have been prioritized. An upstream open reading frame (uORF) in the 5' untranslated region (5' UTR) regulates gene expression at the post-transcription or translation level. In recent years, studies have demonstrated that natural uORF variations shape phenotypic diversity. This opinion article highlights recent researches and speculates on future directions for natural uORF variation in plants.
利用自然变异有助于我们理解表型多样性和性状进化，最终加速植物育种，其中因果变异的鉴定至关重要。迄今为止，编码区的序列变异和由启动子变异引起的转录水平多态性一直是研究重点。5'非翻译区（5'UTR）中的上游开放阅读框（uORF）在转录后或翻译水平调节基因表达。近年来，研究表明自然uORF变异塑造了表型多样性。这篇观点文章重点介绍了近期的研究，并对植物中自然uORF变异的未来方向进行了推测。
