茶碱在妊娠和哺乳期大鼠体内的药代动力学。
Theophylline pharmacokinetics in pregnant and lactating rats.
作者信息
Brandstetter Y, Kaplanski J, van Creveld C, Ben-Zvi Z
出版信息
Res Commun Chem Pathol Pharmacol. 1986 Aug;53(2):269-72.
As a preliminary investigation to a human study, we examined the pharmacokinetics of theophylline in pregnant and lactating rats. Three groups of female rats--pregnant, lactating, and virgin controls were injected IP with theophylline solution. Pregnant rats eliminated theophylline at a slower rate than both lactating rats and virgin controls, resulting in a longer half life (t1/2) and lower clearance. The approximate volume of distribution (aVd) and extrapolated peak concentration (Cp0) in the 3 groups were not different.
作为一项人体研究的初步调查，我们检测了茶碱在妊娠和哺乳期大鼠体内的药代动力学。将三组雌性大鼠（妊娠、哺乳和未孕对照）腹腔注射茶碱溶液。妊娠大鼠清除茶碱的速率比哺乳大鼠和未孕对照均慢，导致半衰期（t1/2）更长且清除率更低。三组的近似分布容积（aVd）和外推峰浓度（Cp0）无差异。
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