Department of Microbiology, Immunology, and Cancer Biology, The University of Virginia, & The UVA Comprehensive Cancer Center, Charlottesville, VA, 22908, USA.
Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Angiogenesis. 2023 Nov;26(4):477-480. doi: 10.1007/s10456-023-09895-4. Epub 2023 Aug 28.
Following the process of vasculogenesis during development, angiogenesis generates new vascular structures through a variety of different mechanisms or modes. These different modes of angiogenesis involve, for example, increasing microvasculature density by sprouting of endothelial cells, splitting of vessels to increase vascular surface area by intussusceptive angiogenesis, fusion of capillaries to increase blood flow by coalescent angiogenesis, and the recruitment of non-endothelial cells by vasculogenic mimicry. The recent reporting on coalescent angiogenesis as a new mode of vessel formation warrants a brief overview of angiogenesis mechanisms to provide a more complete picture. The journal Angiogenesis is devoted to the delineation of the different modes and mechanisms that collectively dictate blood vessel formation, inhibition, and function in health and disease.
在发育过程中的血管发生过程之后，血管生成通过各种不同的机制或模式产生新的血管结构。这些不同的血管生成模式包括例如通过内皮细胞的出芽增加微血管密度，通过分芽增加血管表面积，通过融合血管增加血流，以及通过血管生成模拟招募非内皮细胞。最近关于融合血管生成作为一种新的血管形成模式的报道需要简要概述血管生成机制，以提供更完整的画面。《血管生成》杂志致力于描述不同的模式和机制，这些模式和机制共同决定了血管在健康和疾病中的形成、抑制和功能。
