Deeksha H S, Pajai Sandhya, Cherukuri Srinidhi
Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2023 Jul 28;15(7):e42602. doi: 10.7759/cureus.42602. eCollection 2023 Jul.
Preterm labor, regarded as the onset of labor before 37 weeks of gestation, is a highly prevalent issue in obstetrics with repercussions for neonatal health. This review article presents an in-depth analysis of the alliance between serum magnesium levels and preterm labor. The review explores the physiological roles of magnesium right through pregnancy, including its significance for energy metabolism, smooth muscle contraction, deoxyribonucleic acid (DNA), and protein synthesis. It addresses cellular transport and the homeostasis of magnesium. The pathophysiological processes encompassing inflammation, oxidative stress, calcium regulation, smooth muscle contractility, and neuroendocrine pathways are investigated. The review evaluates epidemiological studies investigating the alliance between serum magnesium levels and preterm labor. The review incorporates an assortment of study varieties, such as observational studies, case-control studies, prospective cohort studies, and meta-analyses. In the course of reviewing the prognostic relevance of serum magnesium levels in premature labor, therapeutic implications involving diagnostic precision, prognostic significance, and therapeutic response assessment have additionally been addressed. Therapeutic interventions targeting magnesium levels, such as magnesium supplementation, tocolytic therapy, and the role of magnesium in antenatal corticosteroid administration, are explored. This review provides an in-depth evaluation of the correlation between serum magnesium levels and preterm labor, stressing its therapeutic significance and repercussions for future research and treatment strategies.
早产被视为妊娠37周前出现的分娩，是产科中一个非常普遍的问题，会对新生儿健康产生影响。这篇综述文章对血清镁水平与早产之间的关联进行了深入分析。该综述探讨了整个孕期镁的生理作用，包括其对能量代谢、平滑肌收缩、脱氧核糖核酸（DNA）和蛋白质合成的重要性。它阐述了镁的细胞转运和体内稳态。研究了包括炎症、氧化应激、钙调节、平滑肌收缩性和神经内分泌途径在内的病理生理过程。该综述评估了调查血清镁水平与早产之间关联的流行病学研究。该综述纳入了各种研究类型，如观察性研究、病例对照研究、前瞻性队列研究和荟萃分析。在回顾血清镁水平在早产中的预后相关性过程中，还探讨了涉及诊断准确性、预后意义和治疗反应评估的治疗意义。探索了针对镁水平的治疗干预措施，如补充镁、宫缩抑制剂治疗以及镁在产前使用糖皮质激素中的作用。这篇综述对血清镁水平与早产之间的相关性进行了深入评估，强调了其治疗意义以及对未来研究和治疗策略的影响。
