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Adult-Onset Still's Disease Presenting as Aseptic Meningitis: A Case Report and Literature Review.成人斯蒂尔病表现为无菌性脑膜炎：一例病例报告及文献综述
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本文引用的文献

1
Elderly-onset adult Still's disease.老年起病型成人斯蒂尔病
Reumatologia. 2021;59(3):188-196. doi: 10.5114/reum.2021.107323. Epub 2021 Jul 11.
2
Adult-onset Still's disease with neurological involvement: a single-centre report.成人斯蒂尔病伴神经系统受累：单中心报告。
Rheumatology (Oxford). 2021 Sep 1;60(9):4152-4157. doi: 10.1093/rheumatology/keaa899.
3
Pathogenesis, disease course, and prognosis of adult-onset Still's disease: an update and review.成人斯蒂尔病的发病机制、疾病过程和预后：更新与综述。
Chin Med J (Engl). 2019 Dec 5;132(23):2856-2864. doi: 10.1097/CM9.0000000000000538.
4
A comprehensive review on adult onset Still's disease.成人斯蒂尔病的全面综述。
J Autoimmun. 2018 Sep;93:24-36. doi: 10.1016/j.jaut.2018.07.018. Epub 2018 Aug 1.
5
Autoimmune meningitis and encephalitis in adult-onset still disease - Case report.成人斯蒂尔病相关自身免疫性脑膜脑炎 - 病例报告。
Neurol Neurochir Pol. 2017 Sep-Oct;51(5):421-426. doi: 10.1016/j.pjnns.2017.06.006. Epub 2017 Jul 8.
6
Tocilizumab in refractory adult-onset Still's disease with aseptic meningitis--efficacy of interleukin-6 blockade and review of the literature.托珠单抗治疗难治性成人斯蒂尔病伴无菌性脑膜炎：白介素-6 阻断的疗效及文献复习。
Semin Arthritis Rheum. 2011 Feb;40(4):365-8. doi: 10.1016/j.semarthrit.2010.05.003.
7
Aseptic meningitis in adult onset Still's disease.成人斯蒂尔病相关性无菌性脑膜炎。
Rheumatol Int. 2012 Dec;32(12):4031-4. doi: 10.1007/s00296-010-1529-8. Epub 2010 May 22.
8
Neutrophilic pleocytosis in cerebrospinal fluid: adult-onset Still's disease.脑脊液中性粒细胞增多：成人斯蒂尔病。
Intern Med. 2003 Oct;42(10):1039-41. doi: 10.2169/internalmedicine.42.1039.
9
Hemophagocytic syndrome and adult Still's disease associated with meningoencephalitis and unconsciousness.噬血细胞综合征及成人斯蒂尔病伴发脑膜脑炎和昏迷。
Intern Med. 2001 Oct;40(10):1037-40. doi: 10.2169/internalmedicine.40.1037.
10
Still's disease can cause neutrophilic meningitis.斯蒂尔病可引起嗜中性粒细胞性脑膜炎。
Neurology. 2000 Mar 14;54(5):1203-5. doi: 10.1212/wnl.54.5.1203.

老年患者以无菌性脑膜炎为表现的成人斯蒂尔病：一例报告

Adult-Onset Still's Disease in an Elderly Patient Presenting as Aseptic Meningitis: A Case Report.

作者信息

Risal Ujjwol, Dhungana Krishna, Ghimire Mrikchhya

机构信息

Department of Internal Medicine, Hospital for Advanced Medicine and Surgery, Dhumbarahi, Nepal.

Department of Neurology, Hospital for Advanced Medicine and Surgery, Dhumbarahi, Nepal.

出版信息

Clin Med Insights Arthritis Musculoskelet Disord. 2023 Aug 24;16:11795441231195636. doi: 10.1177/11795441231195636. eCollection 2023.

DOI:10.1177/11795441231195636
PMID:37641791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10460291/
Abstract

Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disease of unknown origin characterized mainly by fever, arthritis, and a rash. Aseptic meningitis is a rare complication of AOSD and is seen most commonly in young adults. Here, we report a case of AOSD in a 78-year female with fever and altered sensorium with lymphocyte predominant pleocytosis in the cerebrospinal fluid who was initially managed as tubercular meningitis. Adult-onset Still's disease was diagnosed as there was no response to antitubercular drugs even after 3 months and based on persistent fever, inflammatory arthritis, rash, and highly raised inflammatory markers.

摘要

成人斯蒂尔病（AOSD）是一种病因不明的罕见自身炎症性疾病，主要特征为发热、关节炎和皮疹。无菌性脑膜炎是AOSD的一种罕见并发症，最常见于年轻成年人。在此，我们报告一例78岁女性的AOSD病例，该患者有发热和意识改变，脑脊液中淋巴细胞为主的细胞增多，最初被诊断为结核性脑膜炎进行治疗。由于抗结核药物治疗3个月后仍无反应，且基于持续发热、炎性关节炎、皮疹和炎症指标大幅升高，最终诊断为成人斯蒂尔病。