Coppock J S, Scott D L, Carter S D, Moreland T M, Robinson M W
Rheumatol Int. 1986;6(2):79-83. doi: 10.1007/BF00541509.
Fibronectin is involved in the opsonic clearance of particulate material. It is present in plasma and synovial fluid and thus might be expected to have a role in the clearance of immune complexes. We have investigated this in a study of polyethylene glycol (PEG) precipitable material from the serum of patients with rheumatoid arthritis, systemic lupus erythematosus, and other connective tissue disorders. Fibronectin is a significant component of PEG precipitates but the amount present is influenced by the method of preparation: more precipitates at 4 degrees C than at 20 degrees C. Fibronectin precipitation by PEG was considered to be related to immune complexes because: there was no direct relationship between serum fibronectin levels and the amount present in PEG precipitates; radiolabelled purified isolated fibronectin did not precipitate in 4% PEG; there was a direct relationship between the amount of fibronectin in PEG precipitates and the amounts of immunoglobulin G, A, and M. These results indicate that fibronectin is involved in immune complexes in rheumatic diseases, though they do not show it has an important biological role in these circumstances.
纤连蛋白参与颗粒物质的调理清除。它存在于血浆和滑液中，因此可能在免疫复合物的清除中发挥作用。我们在一项针对类风湿关节炎、系统性红斑狼疮和其他结缔组织疾病患者血清中聚乙二醇（PEG）可沉淀物质的研究中对此进行了调查。纤连蛋白是PEG沉淀物的重要组成部分，但其含量受制备方法影响：4℃时的沉淀物比20℃时更多。PEG诱导纤连蛋白沉淀被认为与免疫复合物有关，原因如下：血清纤连蛋白水平与PEG沉淀物中的含量无直接关系；放射性标记的纯化分离纤连蛋白在4%PEG中不沉淀；PEG沉淀物中纤连蛋白的量与免疫球蛋白G、A和M的量存在直接关系。这些结果表明纤连蛋白参与了风湿性疾病中的免疫复合物形成，尽管它们并未表明纤连蛋白在这些情况下具有重要的生物学作用。
