Carter S D, Scott D L, Elson C J
Br J Rheumatol. 1986 Nov;25(4):353-8. doi: 10.1093/rheumatology/25.4.353.
Fibronectin was shown to bind heat-aggregated, but not monomeric, human IgG, suggesting that fibronectin may bind directly to IgG immune complexes. The presence of material both binding and already containing fibronectin was demonstrated in polyethylene glycol precipitates of sera and synovial fluids from patients with rheumatoid arthritis (RA) and gout, but not normal sera. By contrast, complement-fixing complexes contained fibronectin in RA synovial fluids and sera, but not in sera and synovial fluids from other rheumatic disorders. It is considered that fibronectin binds to immune complexes in RA synovial fluids and sera but that some other, as yet unidentified material, is effective in binding fibronectin in sera and synovial fluids from patients with osteoarthritis and crystal synovitis.
已证实纤连蛋白可结合热聚集的人IgG，而非单体形式的人IgG，这表明纤连蛋白可能直接与IgG免疫复合物结合。类风湿关节炎（RA）和痛风患者的血清及滑液经聚乙二醇沉淀后，出现了既结合纤连蛋白又已含有纤连蛋白的物质，但正常血清中未出现。相比之下，补体固定复合物在RA滑液和血清中含有纤连蛋白，而在其他风湿性疾病的血清和滑液中则没有。据认为，纤连蛋白可与RA滑液和血清中的免疫复合物结合，但在骨关节炎和晶体滑膜炎患者的血清和滑液中，某种其他尚未明确的物质在结合纤连蛋白方面起作用。
