Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, School of Plant Protection, Hainan University, Haikou 570228, People's Republic of China.
J Agric Food Chem. 2023 Sep 13;71(36):13209-13219. doi: 10.1021/acs.jafc.3c02580. Epub 2023 Aug 29.
To identify natural nematicides that can replace chemical nematicides, 2-naphthol with high activity against was isolated from . The nematicidal activity of 2-naphthol against was 100% at 100 μg/mL with an EC value of 38.00 μg/mL. Moreover, 2-naphthol had a significant negative effect on egg incubation. 2-Naphthol effectively inhibited the invasion of into crops in both a pot experiment and field trial. In addition, the structure-activity relationship indicated that the naphthalene ring and its β-site hydroxyl group were the key pharmacophores for the nematicidal activity of 2-naphthol. Nematodes were stimulated by 2-naphthol to produce excessive reactive oxygen species, which may be the underlying mechanism of 2-naphthol nematicidal activity. A systemic evaluation of 2-naphthol in tomato plants demonstrated that 2-naphthol remained mainly fixed in the roots after being absorbed by the crop and was not transported to the stems or leaves. Thus, 2-naphthol can be developed as a natural nematicide candidate.
为了寻找可以替代化学杀线虫剂的天然杀线虫剂，从 中分离出对 具有高活性的 2-萘酚。2-萘酚对 的杀线虫活性在 100 μg/mL 时达到 100%，EC 值为 38.00 μg/mL。此外，2-萘酚对卵孵化有显著的负影响。2-萘酚在盆栽试验和田间试验中均能有效抑制 侵入作物。此外，构效关系表明，萘环及其β位羟基是 2-萘酚杀线虫活性的关键药效团。2-萘酚刺激线虫产生过量的活性氧，这可能是 2-萘酚杀线虫活性的潜在机制。对番茄植株中 2-萘酚的系统评价表明，2-萘酚被作物吸收后主要固定在根部，不会运输到茎或叶中。因此，2-萘酚可以开发为一种天然杀线虫剂候选物。
