Patterson T, Spohn H E, Bogia D P, Hayes K
Schizophr Bull. 1986;12(3):460-72. doi: 10.1093/schbul/12.3.460.
Research with schizophrenics is reviewed in the areas of the startle reflex, subject-initiated evoked potentials, and two-stimulus evoked potentials. A hypothesis of an early (pre-100 ms) information-processing deficit is posited and further refined by results presented from brain evoked potentials during a backward-masking experiment. The implications of these findings for the speech component of schizophrenic thought disorder are speculated upon, with specific reference to failures of temporal sequencing control that may underlie schizophrenic speech dysfunction and may be attributable to defective thalamic control. Recent neuroanatomical findings of abnormalities in the hippocampus and thalamus of schizophrenics are presented, and considered as likely contributors to the early information-processing deficits posited.
本文回顾了有关精神分裂症患者在惊吓反射、受试者自发诱发电位和双刺激诱发电位等方面的研究。提出了一个关于早期（100毫秒之前）信息处理缺陷的假说，并通过一项反向掩蔽实验中脑诱发电位的结果对其进行了进一步完善。本文推测了这些发现对精神分裂症思维障碍言语成分的影响，特别提到了时间序列控制失败，这可能是精神分裂症言语功能障碍的基础，并且可能归因于丘脑控制缺陷。本文还介绍了精神分裂症患者海马体和丘脑异常的最新神经解剖学发现，并认为这些发现可能是导致所提出的早期信息处理缺陷的原因。
