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Recent advances in 3D printing of biodegradable metals for orthopaedic applications.

作者信息

Liang Wenqing, Zhou Chao, Zhang Hongwei, Bai Juqin, Jiang Bo, Jiang Chanyi, Ming Wenyi, Zhang Hengjian, Long Hengguo, Huang Xiaogang, Zhao Jiayi

机构信息

Department of Orthopaedics, Zhoushan Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, 355 Xinqiao Road, Dinghai District, Zhoushan, 316000, Zhejiang Province, China.

Department of Orthopedics, Zhoushan Guanghua Hospital, Zhoushan, 316000, China.

出版信息

J Biol Eng. 2023 Aug 29;17(1):56. doi: 10.1186/s13036-023-00371-7.


DOI:10.1186/s13036-023-00371-7
PMID:37644461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10466721/
Abstract

The use of biodegradable polymers for treating bone-related diseases has become a focal point in the field of biomedicine. Recent advancements in material technology have expanded the range of materials suitable for orthopaedic implants. Three-dimensional (3D) printing technology has become prevalent in healthcare, and while organ printing is still in its early stages and faces ethical and technical hurdles, 3D printing is capable of creating 3D structures that are supportive and controllable. The technique has shown promise in fields such as tissue engineering and regenerative medicine, and new innovations in cell and bio-printing and printing materials have expanded its possibilities. In clinical settings, 3D printing of biodegradable metals is mainly used in orthopedics and stomatology. 3D-printed patient-specific osteotomy instruments, orthopedic implants, and dental implants have been approved by the US FDA for clinical use. Metals are often used to provide support for hard tissue and prevent complications. Currently, 70-80% of clinically used implants are made from niobium, tantalum, nitinol, titanium alloys, cobalt-chromium alloys, and stainless steels. However, there has been increasing interest in biodegradable metals such as magnesium, calcium, zinc, and iron, with numerous recent findings. The advantages of 3D printing, such as low manufacturing costs, complex geometry capabilities, and short fabrication periods, have led to widespread adoption in academia and industry. 3D printing of metals with controllable structures represents a cutting-edge technology for developing metallic implants for biomedical applications. This review explores existing biomaterials used in 3D printing-based orthopedics as well as biodegradable metals and their applications in developing metallic medical implants and devices. The challenges and future directions of this technology are also discussed.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/5b3c9d3dac9b/13036_2023_371_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/57ff4958c5db/13036_2023_371_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/60fa1e8372e6/13036_2023_371_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/dc2197ce120b/13036_2023_371_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/bd205afd39be/13036_2023_371_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/84d0d745b88b/13036_2023_371_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/cacbde6d918b/13036_2023_371_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/5b3c9d3dac9b/13036_2023_371_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/57ff4958c5db/13036_2023_371_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/60fa1e8372e6/13036_2023_371_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/dc2197ce120b/13036_2023_371_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/bd205afd39be/13036_2023_371_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/84d0d745b88b/13036_2023_371_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/cacbde6d918b/13036_2023_371_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac53/10466721/5b3c9d3dac9b/13036_2023_371_Fig7_HTML.jpg

相似文献

[1]
Recent advances in 3D printing of biodegradable metals for orthopaedic applications.

J Biol Eng. 2023-8-29

[2]
Three-dimensional printing of metals for biomedical applications.

Mater Today Bio. 2019-8-20

[3]
Binder-jetting 3D printing and alloy development of new biodegradable Fe-Mn-Ca/Mg alloys.

Acta Biomater. 2016-11

[4]
3D-printed patient-specific applications in orthopedics.

Orthop Res Rev. 2016-10-14

[5]
Three-dimensional (3D) synthetic printing for the manufacture of non-biodegradable models, tools and implants used in surgery: a review of current methods.

J Med Eng Technol. 2021-1

[6]
3D printing metal implants in orthopedic surgery: Methods, applications and future prospects.

J Orthop Translat. 2023-9-1

[7]
Novel Biomaterials Used in Medical 3D Printing Techniques.

J Funct Biomater. 2018-2-7

[8]
Recent Advances in Biomaterials for 3D Printing and Tissue Engineering.

J Funct Biomater. 2018-3-1

[9]
Application of 3D Printing Technology in Bone Tissue Engineering: A Review.

Curr Drug Deliv. 2021

[10]
A review on the recent applications of synthetic biopolymers in 3D printing for biomedical applications.

J Mater Sci Mater Med. 2023-11-20

引用本文的文献

[1]
Applications and Effectiveness of 3D Printing in Various Ankle Surgeries: A Narrative Review.

Life (Basel). 2025-3-15

[2]
Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head.

Mater Today Bio. 2025-2-4

[3]
Enhancing Mechanical and Biodegradation Properties of Zn-0.5Fe Alloys Through Rotary Forging.

Materials (Basel). 2025-2-6

[4]
Exploring the frontiers of metal additive manufacturing in orthopaedic implant development.

MethodsX. 2024-11-15

[5]
Nickel-titanium alloy porous scaffolds based on a dominant cellular structure manufactured by laser powder bed fusion have satisfactory osteogenic efficacy.

Mater Today Bio. 2024-11-15

[6]
Functional Scaffolds for Bone Tissue Regeneration: A Comprehensive Review of Materials, Methods, and Future Directions.

J Funct Biomater. 2024-9-25

[7]
Endochondral Ossification for Spinal Fusion: A Novel Perspective from Biological Mechanisms to Clinical Applications.

J Pers Med. 2024-9-9

[8]
A bacteriocin-based coating strategy to prevent vancomycin-resistant biofilm formation on materials of interest for indwelling medical devices.

Biofilm. 2024-7-3

[9]
Structural and temporal dynamics analysis of zinc-based biomaterials: History, research hotspots and emerging trends.

Bioact Mater. 2024-2-10

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