Maddahi Mona, Nattagh-Eshtivani Elyas, Jokar Mohammadhassan, Barati Mehdi, Tabesh Hamed, Safarian Mohammad, Khosravi Maryam
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytother Res. 2023 Dec;37(12):5424-5434. doi: 10.1002/ptr.7996. Epub 2023 Aug 29.
Propolis has gained popularity in recent years because of its beneficial properties, which make it a possible preventative and therapeutic agent as well as a valuable food and cosmetic ingredient. The objective of this study was to evaluate the effects of propolis supplementation on cardiovascular risk factors in women with rheumatoid arthritis. This randomized, double-blind, placebo-controlled clinical trial was performed among 48 patients diagnosed with rheumatoid arthritis. Subjects were randomly assigned to placebo and intervention groups, supplemented with 1000 mg/day of propolis for 12 weeks. Cardiovascular risk factors including, high-sensitivity C-reactive protein (hs-CRP), monocyte chemoattractant protein (MCP-1), Nitric oxide, blood pressure, and lipid profile were assessed pre-and post-intervention. The atherogenic index of plasma value, as well as total cholesterol/high-density lipoprotein cholesterol (HDL-C), triglyceride/HDL-C, and non-HDL-C/HDL-C ratios, were significantly reduced in the intervention group, compared with the placebo group post-intervention (p < 0.05). Moreover, there was a significant reduction in the serum level of hs-CRP in the intervention group when compared with the placebo group (p = 0.001). Furthermore, propolis supplementation could marginally reduce MCP-1 (p = 0.051). These data indicate that propolis supplementation may be a promising treatment strategy for cardiovascular complications among rheumatoid arthritis patients.
近年来，蜂胶因其有益特性而受到欢迎，这些特性使其成为一种可能的预防和治疗剂，也是一种有价值的食品和化妆品成分。本研究的目的是评估补充蜂胶对类风湿性关节炎女性心血管危险因素的影响。这项随机、双盲、安慰剂对照的临床试验在48名被诊断为类风湿性关节炎的患者中进行。受试者被随机分为安慰剂组和干预组，干预组每天补充1000毫克蜂胶，持续12周。在干预前后评估心血管危险因素，包括高敏C反应蛋白（hs-CRP）、单核细胞趋化蛋白（MCP-1）、一氧化氮、血压和血脂谱。与干预后安慰剂组相比，干预组血浆致动脉粥样硬化指数以及总胆固醇/高密度脂蛋白胆固醇（HDL-C）、甘油三酯/HDL-C和非HDL-C/HDL-C比值均显著降低（p<0.05）。此外，与安慰剂组相比，干预组血清hs-CRP水平显著降低（p = 0.001）。此外，补充蜂胶可略微降低MCP-1（p = 0.051）。这些数据表明，补充蜂胶可能是类风湿性关节炎患者心血管并发症的一种有前景的治疗策略。
