Zhang Xueying, Zhong Guangcheng, Wu Haike
The Eighth Clinical Medical College, Guangzhou University of Chinese Medicine, Foshan, 528099, China.
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Pharmacol Rep. 2025 Jun 20. doi: 10.1007/s43440-025-00756-z.
Neurological disorders represent a leading cause of mortality and disability worldwide, encompassing a broad spectrum of prevalent conditions such as Alzheimer's disease, epilepsy, and stroke. In recent years, natural compounds have garnered increasing attention as potential therapeutic and preventive agents for neurological disorders. Galangin, a naturally occurring flavonoid primarily derived from Alpinia officinarum Hance, exhibits diverse biological properties, including notable neuroprotective, anti-tumor, and anti-inflammatory effects. Emerging evidence indicates that galangin exerts significant neuroprotective effects through multiple mechanisms. This review systematically summarizes the in vivo metabolism and pharmacokinetics of galangin, elucidates its mechanism of action, and highlights recent advances in its application for neurological disorders. Furthermore, the prospect of nanodrug carriers for enhancing the therapeutic efficacy of galangin is explored. Additionally, this review addresses the current research limitations and outlines future research directions to provide a theoretical foundation for its clinical application in neurological disorders. Collectively, the findings underscore the extensive pharmacological properties and therapeutic potential of galangin, highlighting its promise as a novel candidate for the treatment and prevention of neurological disorders and warranting further in-depth investigation and development.
神经疾病是全球范围内导致死亡和残疾的主要原因之一，涵盖了广泛的常见病症，如阿尔茨海默病、癫痫和中风。近年来，天然化合物作为神经疾病潜在的治疗和预防药物受到了越来越多的关注。高良姜素是一种主要从高良姜中提取的天然黄酮类化合物，具有多种生物学特性，包括显著的神经保护、抗肿瘤和抗炎作用。新出现的证据表明，高良姜素通过多种机制发挥显著的神经保护作用。本文系统综述了高良姜素的体内代谢和药代动力学，阐明了其作用机制，并重点介绍了其在神经疾病应用方面的最新进展。此外，还探讨了纳米药物载体提高高良姜素治疗效果的前景。此外，本文还讨论了当前的研究局限性，并概述了未来的研究方向，为其在神经疾病中的临床应用提供理论基础。总的来说，这些发现强调了高良姜素广泛的药理特性和治疗潜力，突出了其作为治疗和预防神经疾病的新型候选药物的前景，值得进一步深入研究和开发。
