Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran.
J Health Popul Nutr. 2024 Aug 10;43(1):119. doi: 10.1186/s41043-024-00600-9.
New evidence suggested that propolis might reduce serum levels of inflammatory mediators; therefore, in this study we aimed to prove the potential effect of propolis on serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α) through conducting a systematic review and meta-analysis.
Databases including PubMed, ClinicalTrials.gov, Scopus, Cochrane Library, and ISI Web of Science were searched until October 2023. In the present meta-analysis, we detected the overall effect sizes using extracted standard mean differences (SMD) and the standard deviations (SDs) from both study groups through DerSimonian and Laird method. Exploring the statistical heterogeneity was done through Cochran's Q test and I-squared statistic.
In total, seventeen and sixteen studies were included in the systematic review and meta-analysis, respectively. The overall estimate indicated that the propolis significantly reduced serum levels of IL-6 (SMD = -3.47, 95% confidence interval (95%CI): -5.1, -1.84; p < 0.001), CRP (SMD= -1.73, 95%CI: -2.82, -0.65; p = 0.002), and TNF-α (SMD= -1.42, 95%CI= -2.15, -0.68; p < 0.001). These results also revealed geographical region and propolis dose were the critical points to get the beneficial effects.
According to our result, propolis supplementation can decrease serum levels of IL-6, CRP, and TNF-α; therefore, it might be considered as complementary therapy for the treatment of certain chronic diseases.
新的证据表明，蜂胶可能降低血清中炎症介质的水平；因此，在这项研究中，我们旨在通过系统评价和荟萃分析证明蜂胶对白细胞介素-6（IL-6）、C 反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α）血清水平的潜在影响。
检索了包括 PubMed、ClinicalTrials.gov、Scopus、Cochrane 图书馆和 ISI Web of Science 在内的数据库，检索时间截至 2023 年 10 月。在本荟萃分析中，我们使用提取的标准均数差（SMD）和两组的标准差（SD）通过 DerSimonian 和 Laird 方法检测总体效应大小。通过 Cochran's Q 检验和 I-squared 统计量探索统计异质性。
共有十七项和十六项研究分别被纳入系统评价和荟萃分析。总体估计表明，蜂胶显著降低了 IL-6（SMD = -3.47，95%置信区间[95%CI]：-5.1，-1.84；p < 0.001）、CRP（SMD= -1.73，95%CI：-2.82，-0.65；p = 0.002）和 TNF-α（SMD= -1.42，95%CI= -2.15，-0.68；p < 0.001）的血清水平。这些结果还表明，地理位置和蜂胶剂量是获得有益效果的关键因素。
根据我们的结果，蜂胶补充剂可以降低 IL-6、CRP 和 TNF-α 的血清水平；因此，它可以被认为是治疗某些慢性疾病的辅助治疗方法。
