Wang Taylor, Jain Sumeet, Glidai Yoav, Dua Prachi, Dempsey Katharine S, Shakin Eric, Chu David S, Epstein Marcia, Ha Lawrence G
Dayton and Karen Brown Division of Infectious Diseases, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 400 Community Dr, Manhasset, NY 11030, USA.
Department of Pharmacy, North Shore University Hospital, 300 Community Dr, Manhasset, NY 11030, USA.
IDCases. 2023 Jul 5;33:e01839. doi: 10.1016/j.idcr.2023.e01839. eCollection 2023.
is one of the common gram-negative organisms that cause severe invasive infections in different organ systems. has unique intrinsic mechanisms to develop antimicrobial resistance quickly, making it extremely difficult to treat. We report a case of extensively drug-resistant (XDR) panophthalmitis due to contaminated artificial tears. This report investigates the role of systemic and intravitreal antimicrobials, summarizes the resistance mechanisms of P. aeruginosa, and provides an overview on cefiderocol, a novel antimicrobial that targets multidrug-resistant (MDR) and XDR Gram-negative pathogens.
是导致不同器官系统严重侵袭性感染的常见革兰氏阴性菌之一。具有独特的内在机制，可迅速产生抗菌耐药性，使其极难治疗。我们报告了一例因人工泪液污染导致的广泛耐药（XDR）铜绿假单胞菌全眼球炎病例。本报告研究了全身和玻璃体内抗菌药物的作用，总结了铜绿假单胞菌的耐药机制，并概述了头孢地尔，一种针对多重耐药（MDR）和XDR革兰氏阴性病原体的新型抗菌药物。
