Alhoufie Sari T, Mumena Walaa A, Alsharif Naif, Makhdoom Hatim M, Almutawif Yahya A, Alfarouk Khalid O, Alharbi Mohammed Z, Aljabri Khaled, Aljifri Alanoud
Medical Laboratories Technology Department, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munwarah, Saudi Arabia.
Department of Clinical Nutrition, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munwarah, Saudi Arabia.
Infect Drug Resist. 2023 Aug 24;16:5573-5586. doi: 10.2147/IDR.S419724. eCollection 2023.
The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) increased the demand for intensive care unit (ICU) services. Mortality and morbidity rates among ICU COVID-19 patients are affected by several factors, such as severity, comorbidities, and coinfections. In this study, we describe the demographic characteristics of COVID-19 patients admitted to an ICU in Saudi Arabia, and we determined the predictors for mortality and prolonged ICU length of stay. Additionally, we determined the prevalence of bacterial coinfection and its effect on the outcomes for ICU COVID-19 patients.
We retrospectively studied the medical records of 142 COVID-19 patients admitted to the ICU at a tertiary hospital in Madinah, Saudi Arabia. Data on demographics, medical history, mortality, length of stay, and presence of coinfection were collected for each patient.
Neutrophil-to-Lymphocyte ratio (NLR) and intubation were reliable predictors of mortality and ICU length of stay among these ICU COVID-19 patients. Moreover, bacterial coinfections were detected in 23.2% of the patients and significantly (p < 0.001) prolonged their ICU length of stay, explaining the 10% increase in the length of stay for these patients. Furthermore, mortality reached 70% among the coinfected patients, and 60.8% of the isolated coinfecting pathogens were multidrug-resistant (MDR) strains of , and .
Increased NLR and intubation are predictors of mortality and prolonged length of stay in COVID-19 patients admitted to the ICU. Coinfection with MDR bacterial strains potentially results in complications and is a high-risk factor for prolonged ICU length of stay.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2，新冠病毒）引起的全球大流行增加了重症监护病房（ICU）服务的需求。ICU新冠患者的死亡率和发病率受多种因素影响，如病情严重程度、合并症和合并感染。在本研究中，我们描述了沙特阿拉伯一家ICU收治的新冠患者的人口统计学特征，并确定了死亡率和ICU住院时间延长的预测因素。此外，我们还确定了细菌合并感染的发生率及其对ICU新冠患者预后的影响。
我们回顾性研究了沙特阿拉伯麦地那一家三级医院ICU收治的142例新冠患者的病历。收集了每位患者的人口统计学、病史、死亡率、住院时间和合并感染情况的数据。
中性粒细胞与淋巴细胞比值（NLR）和插管是这些ICU新冠患者死亡率和ICU住院时间的可靠预测因素。此外，23.2%的患者检测到细菌合并感染，这显著（p<0.001）延长了他们的ICU住院时间，解释了这些患者住院时间增加10%的原因。此外，合并感染患者的死亡率达到70%，分离出的合并感染病原体中有60.8%是耐多药（MDR）的 和 菌株。
NLR升高和插管是ICU收治的新冠患者死亡率和住院时间延长的预测因素。耐多药细菌菌株合并感染可能导致并发症，是ICU住院时间延长的高危因素。
