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接受磁共振直线加速器治疗的头颈癌患者的每周治疗期间扩散加权成像数据集

Weekly Intra-Treatment Diffusion Weighted Imaging Dataset for Head and Neck Cancer Patients Undergoing MR-linac Treatment.

作者信息

El-Habashy Dina M, Wahid Kareem A, Renjie He, McDonald Brigid, Mulder Samuel J, Ding Yao, Salzillo Travis, Stephen Lai, Christodouleas John, Dresner Alex, Wang Jihong, Naser Mohamed A, Fuller Clifton D, Mohamed Abdallah Sherif Radwan

机构信息

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Department of Clinical Oncology and Nuclear Medicine, Menoufia University, Shebin Elkom, Egypt.

出版信息

medRxiv. 2023 Aug 20:2023.08.18.23294280. doi: 10.1101/2023.08.18.23294280.

DOI:10.1101/2023.08.18.23294280
PMID:37645931
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10462225/
Abstract

Radiation therapy (RT) is a crucial treatment for head and neck squamous cell carcinoma (HNSCC), however it can have adverse effects on patients' long-term function and quality of life. Biomarkers that can predict tumor response to RT are being explored to personalize treatment and improve outcomes. While tissue and blood biomarkers have limitations, imaging biomarkers derived from magnetic resonance imaging (MRI) offer detailed information. The integration of MRI and a linear accelerator in the MR-Linac system allows for MR-guided radiation therapy (MRgRT), offering precise visualization and treatment delivery. This data descriptor offers a valuable repository for weekly intra-treatment diffusion-weighted imaging (DWI) data obtained from head and neck cancer patients. By analyzing the sequential DWI changes and their correlation with treatment response, as well as oncological and survival outcomes, the study provides valuable insights into the clinical implications of DWI in HNSCC. [Table: see text].

摘要

放射治疗（RT）是头颈部鳞状细胞癌（HNSCC）的关键治疗方法，然而它可能会对患者的长期功能和生活质量产生不利影响。目前正在探索能够预测肿瘤对放疗反应的生物标志物，以实现个性化治疗并改善治疗效果。虽然组织和血液生物标志物存在局限性，但源自磁共振成像（MRI）的成像生物标志物可提供详细信息。MR-Linac系统中MRI与直线加速器的整合实现了磁共振引导放射治疗（MRgRT），可提供精确的可视化和治疗。本数据描述为从头颈癌患者获得的每周治疗期间扩散加权成像（DWI）数据提供了一个有价值的储存库。通过分析连续的DWI变化及其与治疗反应以及肿瘤学和生存结果的相关性，该研究对头颈部鳞状细胞癌中DWI的临床意义提供了有价值的见解。[表：见正文]

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a3/10462225/bb4077c9d018/nihpp-2023.08.18.23294280v1-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a3/10462225/39c69d48b59c/nihpp-2023.08.18.23294280v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a3/10462225/110fe1d0bd16/nihpp-2023.08.18.23294280v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a3/10462225/eb912fb4a838/nihpp-2023.08.18.23294280v1-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a3/10462225/3cf6d353d3ff/nihpp-2023.08.18.23294280v1-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a3/10462225/e92fe9d8d5d1/nihpp-2023.08.18.23294280v1-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a3/10462225/bb4077c9d018/nihpp-2023.08.18.23294280v1-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a3/10462225/39c69d48b59c/nihpp-2023.08.18.23294280v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a3/10462225/110fe1d0bd16/nihpp-2023.08.18.23294280v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a3/10462225/eb912fb4a838/nihpp-2023.08.18.23294280v1-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a3/10462225/3cf6d353d3ff/nihpp-2023.08.18.23294280v1-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a3/10462225/e92fe9d8d5d1/nihpp-2023.08.18.23294280v1-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59a3/10462225/bb4077c9d018/nihpp-2023.08.18.23294280v1-f0006.jpg

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