Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Clinical Oncology and Nuclear Medicine, Menoufia University, Shebin Elkom, Egypt.
Sci Data. 2024 May 11;11(1):487. doi: 10.1038/s41597-024-03217-z.
Radiation therapy (RT) is a crucial treatment for head and neck squamous cell carcinoma (HNSCC); however, it can have adverse effects on patients' long-term function and quality of life. Biomarkers that can predict tumor response to RT are being explored to personalize treatment and improve outcomes. While tissue and blood biomarkers have limitations, imaging biomarkers derived from magnetic resonance imaging (MRI) offer detailed information. The integration of MRI and a linear accelerator in the MR-Linac system allows for MR-guided radiation therapy (MRgRT), offering precise visualization and treatment delivery. This data descriptor offers a valuable repository for weekly intra-treatment diffusion-weighted imaging (DWI) data obtained from head and neck cancer patients. By analyzing the sequential DWI changes and their correlation with treatment response, as well as oncological and survival outcomes, the study provides valuable insights into the clinical implications of DWI in HNSCC.
放射治疗（RT）是头颈部鳞状细胞癌（HNSCC）的重要治疗方法；然而，它会对患者的长期功能和生活质量产生不良影响。目前正在探索能够预测肿瘤对 RT 反应的生物标志物，以实现个体化治疗和改善治疗效果。虽然组织和血液生物标志物存在局限性，但磁共振成像（MRI）衍生的成像生物标志物可提供详细信息。MR-Linac 系统将 MRI 和直线加速器结合在一起，实现了磁共振引导的放射治疗（MRgRT），能够精确地进行可视化和治疗。本数据描述符提供了一个有价值的存储库，用于存储来自头颈部癌症患者的每周治疗内扩散加权成像（DWI）数据。通过分析序列 DWI 变化及其与治疗反应以及肿瘤学和生存结果的相关性，该研究深入探讨了 DWI 在 HNSCC 中的临床意义。
