Crowe J P, Gordon N H, Hubay C A, Pearson O H, Marshall J S, McGuire W L
Surgery. 1986 Oct;100(4):599-605.
As part of a multi-institutional breast cancer data base, 501 stage I, node negative patients have been followed prospectively with a median of 89 months. Patients were treated by a modified radical mastectomy without postoperative therapy. Estrogen receptor (ER) content of the primary tumor was determined in all cases. For the entire patient group at 10 years, the disease-free survival (DFS) rate is 72% and the overall survival (OS) rate is 85%. Both ER value and race (black versus white) were found to be significant prognostic variables for DFS (p = 0.008 and 0.02, respectively) and for OS (p = 0.0001 and 0.01, respectively). ER positive patients had a better DFS and OS rate compared with ER negative patients (74% versus 66% and 90% versus 68%, respectively). Black patients had significantly worse DFS and OS rates compared with white patients (64% versus 74% and 75% versus 86%, respectively). Statistical interaction between the ER and race variables was apparent when comparing the similar DFS for ER positive white (75%), ER negative white (72%), and ER positive black (73%) patients in contrast to a DFS of less than 42% at 10 years for the ER negative black patients. An analysis of the data for the ER negative black patients suggested that the postmenopausal ER negative black patients are at particularly high risk of recurrence and death from breast cancer.
作为多机构乳腺癌数据库的一部分，对501例I期、无淋巴结转移的患者进行了前瞻性随访，中位随访时间为89个月。患者接受改良根治性乳房切除术，术后未进行辅助治疗。所有病例均测定了原发肿瘤的雌激素受体（ER）含量。整个患者组10年时的无病生存率（DFS）为72%，总生存率（OS）为85%。发现ER值和种族（黑人与白人）都是DFS（分别为p = 0.008和0.02）和OS（分别为p = 0.0001和0.01）的显著预后变量。与ER阴性患者相比，ER阳性患者的DFS和OS率更高（分别为74%对66%和90%对68%）。与白人患者相比，黑人患者的DFS和OS率显著更差（分别为64%对74%和75%对86%）。当比较ER阳性白人（75%）、ER阴性白人（72%）和ER阳性黑人（73%）患者相似的DFS时，与ER阴性黑人患者10年时小于42%的DFS相比，ER和种族变量之间的统计学交互作用明显。对ER阴性黑人患者的数据分析表明，绝经后ER阴性黑人患者患乳腺癌复发和死亡的风险特别高。
