Nasonov E L, Solov'ev S K, Ivanova M M, Timofeeva E B, Lekakh I V
Ter Arkh. 1986;58(7):49-54.
Twenty SLE patients were examined against a background of pulse-therapy with methylprednisolone. The analysis showed that there was a decrease in the CIC concentration, antibodies to native DNA and an increase in the level of C3c and C4 components of the complement against a background of pulse-therapy. A more rapid time course of the CIC level was noted shortly after pulse-therapy as compared to changes in other immunological indices. A dynamic study of immunological indices in SLE against a background of pulse-therapy was appropriate for a clinical assessment and a study of the mechanisms responsible for the therapeutic efficacy of this method.
对20例系统性红斑狼疮（SLE）患者在甲泼尼龙冲击治疗的背景下进行了检查。分析表明，在冲击治疗的背景下，循环免疫复合物（CIC）浓度降低，抗天然DNA抗体减少，补体C3c和C4成分水平升高。与其他免疫指标的变化相比，在冲击治疗后不久就注意到CIC水平有更快的变化过程。在冲击治疗背景下对SLE患者免疫指标进行动态研究，对于临床评估以及研究该方法治疗效果的作用机制是合适的。
