Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Immun Inflamm Dis. 2023 Aug;11(8):e960. doi: 10.1002/iid3.960.
Oral lichen planus (OLP) is a chronic inflammatory disorder with cell-induced immunopathological responses and is considered a potential malignancy disorder in the oral cavity. Due to the high prevalence of OLP as well as the potential for malignancy, human papillomaviruses (HPVs) may play an important role in it. Although previous studies have explored the possible relationship between HPV and OLP, the findings have been conflicting and nonconclusive. This study aims to review the studies that investigated HPV-16 and HPV-18 in OLP.
The research protocol followed the Preferred Reporting Items for Systematic Reviews (PRISMA2020) checklist. The online databases Pubmed, Scopus, Embase, Google Scholar, and Cochrane were searched using the following individual keywords: "OLP" OR "Oral Lichen Planus" OR "HPV" OR "Human Papillomavirus." The search strategy resulted in the selection of 80 articles. The articles were evaluated, and after duplication removal, 53 abstracts were reviewed, resulting in the selection of 25 studies according to inclusion and exclusion criteria. The risk of bias assessment was done by using the Modified Newcastle-Ottawa quality assessment scale. The overall prevalence of HPV in OLP lesions varied from 2.7% to 70%, depending on the type of diagnostic method used.
Despite the studies conducted on the relationship between OLP and HPV infection, there is still no conclusive evidence that HPV can play a role in the etiopathogenesis of OLP, either in clinical manifestations or in the malignant transformation of lesions.
口腔扁平苔藓（OLP）是一种慢性炎症性疾病，具有细胞诱导的免疫病理反应，被认为是口腔潜在的恶性疾病。由于 OLP 的高患病率以及恶性转化的潜在风险，人乳头瘤病毒（HPV）可能在其中发挥重要作用。尽管先前的研究已经探讨了 HPV 与 OLP 之间的可能关系，但研究结果存在冲突且不明确。本研究旨在回顾调查 OLP 中 HPV-16 和 HPV-18 的研究。
研究方案遵循系统评价的首选报告项目（PRISMA2020）清单。使用以下单独的关键词在在线数据库 Pubmed、Scopus、Embase、Google Scholar 和 Cochrane 上进行搜索：“OLP”或“口腔扁平苔藓”或“HPV”或“人乳头瘤病毒”。搜索策略导致选择了 80 篇文章。对文章进行评估，并在去除重复项后，对 53 篇摘要进行了审查，根据纳入和排除标准选择了 25 项研究。使用改良的纽卡斯尔-渥太华质量评估量表进行偏倚风险评估。根据使用的诊断方法的不同，OLP 病变中 HPV 的总患病率从 2.7%到 70%不等。
尽管已经进行了关于 OLP 与 HPV 感染之间关系的研究，但仍没有确凿的证据表明 HPV 可以在 OLP 的发病机制中发挥作用，无论是在临床表现还是在病变的恶性转化中。
