Department of Immunopathology and Molecular Biology, Wroclaw Medical University, Poland.
Department of Oral Pathology, Wroclaw Medical University, Poland.
Acta Otorhinolaryngol Ital. 2021 Dec;41(6):514-522. doi: 10.14639/0392-100X-N1450.
Oral lichen planus (OLP) is a chronic inflammatory disease. There are no markers that can be used to identify the risk of a malignant transformation of OLP to oral squamous cell carcinoma (OSCC).
Immunohistochemical staining was performed among 56 patients with OLP and 66 patients with OSCC for p53, HSP90 and E-cadherin expression and presence of HPV16/18.
Significant differences in p53 and HSP90 expression between OLP and OSCC were found ( = 0.01 and = 0.006, respectively). A positive correlation between HSP90 and p53 expression was seen in OLP ( = 0.017). Univariate analysis identified HSP90 expression and HPV16/18 presence as prognostic factors for overall survival time (OS) ( < 0.05). In multivariate analysis, only HSP90 expression was an independent prediction factor for shorter OS of OSCC patients ( = 0.016).
The present study suggests that cooperation between p53 and HSP90 as well as between HPV16/18 and HSP90 exists in OLP and may affect the biological behaviour of OLP. The observed expression of HSP90 and p53 in OLP and their increase in OSCC suggests that these proteins participate in the malignant transformation of OLP. HSP90 may be a potential independent prognostic biomarker that can predict poor prognosis in OSCC.
口腔扁平苔藓（OLP）是一种慢性炎症性疾病。目前尚无可用于识别 OLP 向口腔鳞状细胞癌（OSCC）恶性转化风险的标志物。
对 56 例 OLP 患者和 66 例 OSCC 患者进行 p53、HSP90 和 E-钙黏蛋白表达及 HPV16/18 检测。
OLP 和 OSCC 之间的 p53 和 HSP90 表达存在显著差异（=0.01 和=0.006）。OLP 中 HSP90 和 p53 表达呈正相关（=0.017）。单因素分析确定 HSP90 表达和 HPV16/18 存在是 OS 总生存时间（OS）的预后因素（<0.05）。多因素分析显示，仅 HSP90 表达是 OSCC 患者 OS 较短的独立预测因子（=0.016）。
本研究表明，p53 和 HSP90 之间以及 HPV16/18 和 HSP90 之间存在协同作用，可能影响 OLP 的生物学行为。在 OLP 中观察到 HSP90 和 p53 的表达及其在 OSCC 中的增加表明这些蛋白参与了 OLP 的恶性转化。HSP90 可能是一种潜在的独立预后生物标志物，可预测 OSCC 的不良预后。
