Mikhaĭlova N A, Mazneva L M, Konovalov G A, Demidova T V, Kulakov G P
Ter Arkh. 1986;58(8):105-11.
The authors compared 2 methods of apheresis: plasmapheresis (PA) and lymphocytoplasmapheresis (LPA) in 24 patients with rheumatoid arthritis (RA). Both methods were shown to produce a positive effect on a course of rheumatoid process decreasing clinical and laboratory parameters of its activity, improving articular function. Under LPA influence the production of autoantibodies by B-lymphocytes was significantly lowered. PA and LPA were characterized by a more rapid development of the regression of RA symptoms as compared to drug therapy and by a good tolerance of the procedures. On the basis of the results obtained a preliminary conclusion has been made of the greater efficacy of LPA as compared to that of PA. However, the assessment of long-term therapeutic results is required to consider the probable LPA influence on cellular immunity.
作者对24例类风湿关节炎（RA）患者的两种血液成分分离方法进行了比较：血浆置换（PA）和淋巴细胞血浆置换（LPA）。结果表明，两种方法均对类风湿病程产生积极影响，降低了其活动的临床和实验室参数，改善了关节功能。在LPA的影响下，B淋巴细胞产生自身抗体的水平显著降低。与药物治疗相比，PA和LPA的特点是RA症状消退更快，且对这些操作耐受性良好。根据所得结果，初步得出结论，LPA比PA更有效。然而，需要评估长期治疗结果，以考虑LPA对细胞免疫可能产生的影响。
