Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas (FCM), Departamento de Otorrinolaringologia, Cirurgia de Cabeça e Pescoço, Campinas, SP, Brazil.
Hospital Universitário Cajuru, Departamento de Otorrinolaringologia, Curitiba, PR, Brazil.
Braz J Otorhinolaryngol. 2023 Sep-Oct;89(5):101303. doi: 10.1016/j.bjorl.2023.101303. Epub 2023 Aug 17.
To review and provide evidence-based recommendations for the diagnosis and treatment of otosclerosis.
Task force members were educated on knowledge synthesis methods, including electronic database search, review and selection of relevant citations, and critical appraisal of selected studies. Articles written in English or Portuguese on otosclerosis were eligible for inclusion. The American College of Physicians' guideline grading system and the American Thyroid Association's guideline criteria were used for critical appraisal of evidence and recommendations for therapeutic interventions.
The topics were divided into 2 parts: 1) Diagnosis - audiologic and radiologic; 2) Treatment - hearing AIDS, pharmacological therapy, stapes surgery, and implantable devices - bone-anchored devices, active middle ear implants, and Cochlear Implants (CI).
The pathophysiology of otosclerosis has not yet been fully elucidated, but environmental factors and unidentified genes are likely to play a significant role in it. Women with otosclerosis are not at increased risk of worsening clinical condition due to the use of contraceptives or during pregnancy. Drug treatment has shown little benefit. If the patient does not want to undergo stapedotomy, the use of hearing aids is well indicated. Implantable systems should be indicated only in rare cases, and the CI should be indicated in cases of profound deafness.
回顾并提供耳硬化症的诊断和治疗的循证建议。
工作组的成员接受了知识综合方法的培训,包括电子数据库搜索、相关引文的审查和选择,以及对选定研究的批判性评估。纳入的研究为发表于英文或葡萄牙文的关于耳硬化症的文章。采用美国医师学院的指南分级系统和美国甲状腺协会的指南标准对证据进行批判性评估,并对治疗干预措施提出建议。
这些主题分为 2 部分:1)诊断-听力和影像学;2)治疗-助听器、药物治疗、镫骨手术和植入物-骨锚式设备、主动中耳植入物和人工耳蜗(CI)。
耳硬化症的病理生理学尚未完全阐明,但环境因素和未识别的基因可能在其中发挥重要作用。耳硬化症女性使用避孕药或怀孕期间临床状况恶化的风险不会增加。药物治疗的效果甚微。如果患者不想接受镫骨切除术,使用助听器是很好的选择。植入系统仅应在极少数情况下使用,而 CI 应在重度耳聋的情况下使用。