ISGlobal, Hospital Clinic-University of Barcelona, Barcelona, Spain.
Sandra-Rotman Centre for Global Health, Toronto General Research Institute, University Health Network-Toronto General Hospital, Toronto, Ontario, Canada.
J Infect Dis. 2024 Jan 12;229(1):183-188. doi: 10.1093/infdis/jiad373.
Malaria can cause brain injury. Neurofilament light chain (NfL) is a biomarker of neuronal damage. Here we examined longitudinal plasma NfL levels in children aged 1-12 years with uncomplicated and severe malaria from Mozambique. NfL levels were similar in all malaria cases at hospital admission. However, levels increased over time and the increment was significantly higher in severe malaria cases with neurological manifestations (ie, coma, impaired consciousness, or repeated seizures). NfL may be useful to identify and quantify brain injury in malaria.
疟疾可导致脑损伤。神经丝轻链（NfL）是神经元损伤的生物标志物。在此，我们研究了莫桑比克 1-12 岁患有无并发症和严重疟疾儿童的纵向血浆 NfL 水平。入院时，所有疟疾病例的 NfL 水平相似。然而，随着时间的推移，水平逐渐升高，且伴有神经表现（即昏迷、意识障碍或反复癫痫发作）的严重疟疾病例的升高幅度显著更高。NfL 可能有助于识别和定量疟疾导致的脑损伤。
