DICMaPI, Università degli Studi di Napoli Federico II, P. le Tecchio 80, 80125 Napoli, Italy.
Dipartimento di Chimica, Materiali e Ingegneria Chimica "G. Natta", Politecnico di Milano, via Mancinelli 7, I-20131 Milano (MI), Italy.
Int J Pharm. 2023 Sep 25;644:123353. doi: 10.1016/j.ijpharm.2023.123353. Epub 2023 Aug 28.
In recent years, advancements in bioengineering and materials science have witnessed increasing interest in synthetic polymers capable of fulfilling various applications. Owing to their distinctive properties, Pluronics can be used as nano-drug carriers, to deliver poorly water-soluble drugs, and as model systems to study colloidal science by tuning amphiphilic properties. In this work, we investigated the effect of diclofenac sodium on the self-assembly and thermoresponsive crystallization of Pluronic F68 in water solutions, by employing experimental rheology and Nuclear Magnetic Resonance (NMR). We built a complete phase diagram as a function of temperature and concentration for 45 wt% Pluronic F68 with various amounts of diclofenac sodium in water. The morphological transitions were followed as a function of temperature via linear rheology. We extrapolated the transition temperatures - identifying distinct phases - as a function of the drug concentration and proposed an empirical model for their prediction. NMR analysis provided further information on the structural characteristics of the systems, shedding light on the interactions between F68 and diclofenac sodium. Although dealing with a pharmaceutical salt, the study is focused on a colloidal system and its interaction with a binding molecule, that is of general interest for colloidal science.
近年来，生物工程和材料科学的进步使得人们对能够满足各种应用需求的合成聚合物越来越感兴趣。由于其独特的性质，Pluronics 可以用作纳米药物载体，输送水溶性差的药物，并作为胶体科学的模型系统，通过调整两亲性来研究胶体科学。在这项工作中，我们通过实验流变学和核磁共振（NMR）研究了双氯芬酸钠对 Pluronic F68 在水溶液中的自组装和温敏结晶的影响。我们构建了一个完整的相图，作为温度和浓度的函数，对于 45wt%的 Pluronic F68 在水中含有不同量的双氯芬酸钠。通过线性流变学跟踪形态转变作为温度的函数。我们推断出转变温度 - 确定不同的相 - 作为药物浓度的函数，并提出了一个经验模型来预测它们。NMR 分析提供了关于系统结构特征的进一步信息，揭示了 F68 和双氯芬酸钠之间的相互作用。尽管涉及一种药物盐，但该研究侧重于胶体系统及其与结合分子的相互作用，这对胶体科学具有普遍的兴趣。
