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肺移植术后房性心律失常的处理。

Management of Atrial Arrhythmias After Lung Transplant.

机构信息

Montefiore-Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Department of Anesthesiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, USA; Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg-Essen, Essen, Germany.

出版信息

JACC Clin Electrophysiol. 2023 Aug;9(8 Pt 3):1824-1835. doi: 10.1016/j.jacep.2023.01.021. Epub 2023 Mar 22.

Abstract

The overall survival in patients undergoing lung transplantation is poor. Although postsurgical atrial arrhythmias seem to play a major role in the morbidity and mortality of this population, data regarding the clinical and interventional management of this complication are still controversial. Through a review of the literature in the field, we observed that not only the surgical technique is clearly arrhythmogenic, but the new administration of peri-procedure beta-blockers and amiodarone for arrhythmia prevention and treatment, respectively, seems harmful in these postsurgical patients. However, low-dose beta-blockers administered after surgery seem feasible in arrhythmia prevention in specific patient subgroups, and, aside from amiodarone, alternative antiarrhythmic agents can be safely and effectively used to treat symptomatic patients on top of adequate rate control. Finally, as to complex atrial arrhythmias occurring late after lung transplant surgery, radiofrequency catheter ablation seems a feasible treatment option. In light of this evidence and considering the absence of clear recommendations in the field, we suggest a practical approach that may help the clinician in the management of this postsurgical complication. However, as most of these considerations are drawn from small-sized and retrospective studies, more evidence is needed in the future to clarify which medical and interventional strategies may best treat these postsurgical arrhythmias and thus potentially improve the outcome of these frail patients.

摘要

肺移植患者的总体生存率较差。尽管术后房性心律失常似乎是该人群发病率和死亡率的主要原因,但关于这种并发症的临床和介入治疗的数据仍存在争议。通过对该领域文献的回顾,我们观察到不仅手术技术明显有致心律失常作用,而且新的围手术期β受体阻滞剂和胺碘酮的应用分别用于预防和治疗心律失常似乎对这些术后患者有害。然而,在特定患者亚组中,术后给予低剂量β受体阻滞剂似乎可以预防心律失常,除胺碘酮外,替代抗心律失常药物可在充分控制心率的基础上安全有效地用于治疗有症状的患者。最后,对于肺移植手术后晚期发生的复杂房性心律失常,射频导管消融似乎是一种可行的治疗选择。鉴于这些证据,并考虑到该领域缺乏明确的建议,我们提出了一种实用的方法,可能有助于临床医生处理这种术后并发症。然而,由于这些考虑大多来自于小规模和回顾性研究,未来需要更多的证据来阐明哪些药物和介入策略可能最有效地治疗这些术后心律失常,从而有可能改善这些脆弱患者的预后。

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