Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA; School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, U.K..
Sleep Health. 2024 Feb;10(1S):S149-S153. doi: 10.1016/j.sleh.2023.07.012. Epub 2023 Aug 28.
We examined whether the endogenous circadian timing system modulates proxies of mood vulnerability and well-being.
Nineteen healthy participants (mean age: 26.6 years [23.0-30.2], seven females, body-mass index: 22.8 kg/m [21.1-25]) completed a laboratory protocol with a 32-hour Constant Routine, a stringently controlled protocol designed to isolate assessment of endogenous circadian rhythms. We assessed hourly anxiety- and depression-like mood (i.e., those typically observed in depression and anxiety) and well-being (i.e., associated with mental fatigue and physical comfort).
Significant endogenous circadian rhythms were observed in anxiety-like and depression-like mood, as well as well-being (p values from the mixed-model analysis using false discovery rates < .001). Post-hoc comparisons revealed more anxiety-like and depression-like mood during the circadian phase 60°-75° (∼8-9 a.m.), and more mental fatigue and less physical comfort during the circadian phase 30°-60° (∼6-8 a.m.).
Our data indicate endogenous circadian rhythms in anxiety-like and depression-like mood and well-being in healthy young adults. Future studies will help establish circadian-based therapeutics for individuals experiencing mood and anxiety disorders.
我们研究了内源性昼夜节律计时系统是否调节情绪脆弱性和幸福感的替代指标。
19 名健康参与者（平均年龄：26.6 岁[23.0-30.2]，7 名女性，体重指数：22.8kg/m[21.1-25]）完成了一项 32 小时恒常作息的实验室方案，这是一项严格控制的方案，旨在分离内源性昼夜节律的评估。我们每小时评估焦虑和抑郁样情绪（即通常在抑郁和焦虑中观察到的情绪）和幸福感（即与精神疲劳和身体舒适度相关的情绪）。
在焦虑样和抑郁样情绪以及幸福感方面观察到明显的内源性昼夜节律（使用错误发现率的混合模型分析的 p 值<.001）。事后比较显示，在昼夜相位 60°-75°（约 8-9 点）时出现更多的焦虑样和抑郁样情绪，在昼夜相位 30°-60°（约 6-8 点）时出现更多的精神疲劳和较少的身体舒适度。
我们的数据表明，健康年轻成年人的焦虑样和抑郁样情绪以及幸福感存在内源性昼夜节律。未来的研究将有助于为患有情绪和焦虑障碍的个体建立基于昼夜节律的治疗方法。
