Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, 278# Bao Guang Road, Xindu District, Chengdu, 610000, Sichuan, People's Republic of China.
Department of Gastroenterology, The Sixth People's Hospital of Chengdu, Chengdu, Sichuan, China.
Sci Rep. 2023 Aug 30;13(1):14247. doi: 10.1038/s41598-023-36754-5.
The minority people panmicrobial community database (MPPCD website: http://mppmcdb.cloudna.cn/ ) is the first microbe-disease association database of Chinese ethnic minorities. To research the relationships between intestinal microbes and diseases/health in the ethnic minorities, we collected the microbes of the Han people for comparison. Based on the data, such as age, among the different ethnic groups of the different regions of Sichuan Province, MPPCD not only provided the gut microbial composition but also presented the relative abundance value at the phylum, class, order, family and genus levels in different groups. In addition, differential analysis was performed in different microbes in the two different groups, which contributed to exploring the difference in intestinal microbe structures between the two groups. Meanwhile, a series of related factors, including age, sex, body mass index, ethnicity, physical condition, and living altitude, were included in the MPPCD, with special focus on living altitude. To date, this is the first intestinal microbe database to introduce altitude features. In conclusion, we hope that MPPCD will serve as a fundamental research support for the relationship between human gut microbes and host health and disease, especially in ethnic minorities.
少数民族泛微生物群落数据库（MPPCD 网站：http://mppmcdb.cloudna.cn/）是中国少数民族中第一个微生物-疾病关联数据库。为了研究少数民族人群肠道微生物与疾病/健康之间的关系，我们收集了汉族人群的微生物进行比较。基于四川省不同地区不同民族的年龄等数据，MPPCD 不仅提供了肠道微生物组成，还在门、纲、目、科和属水平上呈现了不同群体的相对丰度值。此外，对两组不同微生物进行了差异分析，有助于探索两组人群肠道微生物结构的差异。同时，MPPCD 中还包含了一系列相关因素，包括年龄、性别、体重指数、民族、身体状况和生活海拔高度，特别关注生活海拔高度。迄今为止，这是第一个引入海拔特征的肠道微生物数据库。总之，我们希望 MPPCD 将作为研究人类肠道微生物与宿主健康和疾病关系的基础研究支持，特别是在少数民族中。
