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恒河猴在接受表达 HIV 抗原的 rVSV 载体疫苗的异源方案免疫后，对重复的 SHIV 直肠内暴露显示出更强的抵抗力。

Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen.

机构信息

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.

出版信息

Emerg Microbes Infect. 2023 Dec;12(2):2251595. doi: 10.1080/22221751.2023.2251595.

DOI:10.1080/22221751.2023.2251595
PMID:37649434
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10486302/
Abstract

Despite the human immunodeficiency virus (HIV) pandemic continuing worldwide for 40 years, no vaccine to combat the disease has been licenced for use in at risk populations. Here, we describe a novel recombinant vesicular stomatitis virus (rVSV) vector vaccine expressing modified HIV envelope glycoproteins and Ebola virus glycoprotein. Three heterologous immunizations successfully prevented infection by a different clade SHIV in 60% of non-human primates (NHPs). No trend was observed between resistance and antibody interactions. Resistance to infection was associated with high proportions of central memory T-cell CD69 and CD154 marker upregulation, increased IL-2 production, and a reduced IFN-γ response, offering insight into correlates of protection.

摘要

尽管人类免疫缺陷病毒（HIV）大流行已经在全球持续了 40 年，但尚未有针对该疾病的疫苗获得许可并用于高危人群。在这里，我们描述了一种新型的重组水疱性口炎病毒（rVSV）载体疫苗，该疫苗表达了修饰后的 HIV 包膜糖蛋白和埃博拉病毒糖蛋白。三次异源免疫接种成功地使 60%的非人类灵长类动物（NHPs）免受不同谱系 SHIV 的感染。在耐药性和抗体相互作用之间没有观察到趋势。对感染的抵抗力与中央记忆 T 细胞 CD69 和 CD154 标志物上调的高比例、IL-2 产生的增加以及 IFN-γ 反应的减少有关，这为保护相关因素提供了深入了解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ea/10486302/c7761211fb77/TEMI_A_2251595_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ea/10486302/44acd582edbb/TEMI_A_2251595_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ea/10486302/961e361df70b/TEMI_A_2251595_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ea/10486302/71a1a197a322/TEMI_A_2251595_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ea/10486302/bf4c91551887/TEMI_A_2251595_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ea/10486302/24f33f28fe8a/TEMI_A_2251595_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ea/10486302/c7761211fb77/TEMI_A_2251595_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ea/10486302/44acd582edbb/TEMI_A_2251595_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ea/10486302/961e361df70b/TEMI_A_2251595_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ea/10486302/71a1a197a322/TEMI_A_2251595_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ea/10486302/bf4c91551887/TEMI_A_2251595_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ea/10486302/24f33f28fe8a/TEMI_A_2251595_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67ea/10486302/c7761211fb77/TEMI_A_2251595_F0005_OC.jpg

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