Doğan Zeynal, Kekilli Murat
Ankara Education and Research Hospital, Department of Gastroenterology, Ankara, Turkey.
Pract Lab Med. 2023 Jun 25;36:e00319. doi: 10.1016/j.plabm.2023.e00319. eCollection 2023 Aug.
Neutrophil to lymphocyte ratio (NLR), a novel inflammatory marker, has been shown to increase in various systemic inflammatory conditions. In this way, we want to evaluate the relationship between the presence of , duodenal ulcer related and NLR in dyspeptic patients.
The patients were divided into three groups after evaluating of the EGD and histopathology results. The groups were determined as follow; Group A: positive and DU negative, Group B: positive and DU positive, Group C: negative and DU negative. Then, groups were compared with each other for demographic features, laboratory tests and NLR.
There were significant differences between groups for NLR when groups compared with each other. Significantly high NLR was seen in group A ( positive, DU negative) and group B ( positive, DU positive) when compared with group C ( negative, DU negative) (respectively p < 0.042, p < 0.001). Significantly higher NLR was determined in the group B when compared with group A and group C (respectively p < 0.021, p < 0.001). The cut-off value for NLR was 2,17 with a specificity of 61% and sensitivity of 66% for group B comparing with Group C (AUC:0,66).
Significantly higher NLR was determined in patients with and DU. As a result, NLR may be used as a non-invasive test for documenting the presence of and related DU.
中性粒细胞与淋巴细胞比值（NLR）是一种新型炎症标志物，已证实在各种全身性炎症状态下会升高。通过这种方式，我们想评估消化不良患者中幽门螺杆菌（Hp）的存在、十二指肠溃疡（DU）与NLR之间的关系。
在评估内镜检查和组织病理学结果后，将患者分为三组。分组如下：A组：Hp阳性且DU阴性；B组：Hp阳性且DU阳性；C组：Hp阴性且DU阴性。然后，比较三组患者的人口统计学特征、实验室检查和NLR。
三组之间相互比较时，NLR存在显著差异。与C组（Hp阴性，DU阴性）相比，A组（Hp阳性，DU阴性）和B组（Hp阳性，DU阳性）的NLR显著升高（分别为p < 0.042，p < 0.001）。与A组和C组相比，B组的NLR显著更高（分别为p < 0.021，p < 0.001）。与C组相比，B组NLR的截断值为2.17，特异性为61%，敏感性为66%（曲线下面积：0.66）。
Hp和DU患者的NLR显著更高。因此，NLR可作为一种无创检测方法，用于证明Hp及与Hp相关的DU的存在。
