Ogino Shuichi, Yamada Atsushi, Nakano Takashi, Lee Sunghee, Yamanaka Hiroki, Tsuge Itaru, Sowa Yoshihiro, Sakamoto Michiharu, Kyoko Fukazawa, Kambe Yusuke, Kato Yuki, Arata Jun, Yamauchi Koji, Yamaoka Tetsuji, Morimoto Naoki
Department of Plastic and Reconstructive Surgery, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.
Department of Research and Development for Innovative Medical Devices and Systems, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.
Regen Ther. 2023 Aug 24;24:324-331. doi: 10.1016/j.reth.2023.08.004. eCollection 2023 Dec.
The regeneration of adipose tissue in patients after breast cancer surgery would be desirable without the use of growth factors or cells to avoid potential recurrence and metastasis. We reported that prolate spheroidal-shaped poly-L-lactic acid (PLLA) mesh implants of approximately 18-mm polar diameter and 7.5-mm greatest equatorial diameter containing collagen sponge (CS) would be replaced by regenerated adipose tissue after implantation, thereby suggesting an innovative method for breast reconstruction. Our study aimed to evaluate the adipose tissue regeneration ability of implant aggregates in a porcine model.
We prepared implant aggregates consisting of thirty PLLA mesh implants containing CS packed in a woven poly (glycolic acid) bag. The implant aggregates were inserted under the mammary glands in the porcine abdomen for a year. Single and double groups were classified by inserting either one or two implant aggregates on each side of the abdomen, respectively.
In both groups, the volume of the implant aggregates decreased over time, and the formation of adipose tissue peaked between 6 and 9 months. Histologically, the formation of adipose tissue was confirmed in the area that was in contact with native adipose tissue.
Our implant aggregates could induce the autologous adipose tissue after long term implantation , without the use of any growth factor or cell treatment, presenting a potential novel method of breast reconstruction.
乳腺癌手术后患者的脂肪组织再生是理想的，无需使用生长因子或细胞以避免潜在的复发和转移。我们报道，植入后，极径约18毫米、最大赤道直径7.5毫米且含有胶原海绵（CS）的扁长球形聚-L-乳酸（PLLA）网状植入物会被再生脂肪组织替代，从而提示了一种创新的乳房重建方法。我们的研究旨在评估猪模型中植入物聚集体的脂肪组织再生能力。
我们制备了由30个含CS的PLLA网状植入物组成的植入物聚集体，将其包装在编织的聚乙醇酸袋中。将植入物聚集体植入猪腹部乳腺下方一年。单组和双组分别通过在腹部每侧插入一个或两个植入物聚集体进行分类。
在两组中，植入物聚集体的体积随时间减少，脂肪组织形成在6至9个月达到峰值。组织学上，在与天然脂肪组织接触的区域证实了脂肪组织的形成。
我们的植入物聚集体在长期植入后可诱导自体脂肪组织形成，无需使用任何生长因子或细胞治疗，为乳房重建提供了一种潜在的新方法。
